GER can result in abnormal esophageal motility characterized by weakened primary esophageal peristalsis.
Up to 50% of patients with GERD will have motility disorders ("nonspecific motility disorder") where there is diminished primary esophageal peristalsis.
Total fundoplication is superior to partial fundoplication even when esophageal peristalsis is weak.
Manometry will show a normal proximal (striated muscle) esophagus with low or absent distal esophageal peristalsis
and low LES pressure.
Patients with fundoplication (n = 4) had 45% of swallows followed by abnormal esophageal peristalsis versus 17% in those without fundoplication (P < 0.
Conclusions: Decreased esophageal peristalsis is a common finding in Rett patients with symptoms of GERD and dysphagia with or without fundoplication.
Esophageal peristalsis was considered abnormal if less than 80% of waves propagated in an antegrade direction, or if the peak amplitude of contraction was greater than 100 mmHg or less than 30 mmHg.
The optimal treatment of the disease would improve esophageal peristalsis
and promote lower esophageal sphincter relaxation.
Levine and Ilowite discovered that six of the eight breast-fed children had problems with esophageal peristalsis
, the involuntary waves that push food down this digestive tube.
The normal esophagus is a muscular tube that contracts in order to push the food towards the stomach, a function called esophageal peristalsis
One intriguing aspect of it is that esophageal peristalsis
can be inhibited and even stopped by repeated swallowing.
It has also been suggested that CEA may be associated with abnormal esophageal peristalsis