esophageal glands


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e·soph·a·ge·al glands

a variable number of small compound mucous glands in the submucosa of the esophagus.
References in periodicals archive ?
2) Vitamin A deficiency results in squamous metaplasia of the esophageal glands leading to secondary infections.
All 14 cases containing NNEM, including squamous epithelium, metaplastic columnar epithelium without goblet cells, and submucosal esophageal glands, showed no staining for IMP3.
In a comparison study of the relationship among the distal end of esophageal longitudinal vessels, the proximal end of gastric mucosal folds, and the most distal end of deep esophageal glands and ducts, Sato et al (17) systematically investigated the entire EGJ in 87 consecutive resection specimens from patients with esophageal squamous cell carcinoma.
In a histologic study of the EGJ in 44 resection specimens for gastric cardiac cancer in Chinese patients, among which the entire EGJ was examined microscopically in 31 cases, Fan et al (23) used the most distal end of squamous mucosa, along with deep esophageal glands and ducts, as the histologic landmarks of the mucosal EGJ.
Recent histopathologic studies have characterized the morphologic features of the mucosal EGJ and defined the following histologic features of the mucosal EGJ as the distal ends of (1) squamous mucosa or islands (Figure 4); (2) deep esophageal glands and ducts (Figure 5); (3) multilayered epithelium (Figure 6) and hybrid glands; and (4) double-layered muscularis mucosa.
Squamous mucosa and deep esophageal glands and ducts are unique to the esophagus and absent in the stomach.
At present, the best histologic markers of the mucosal EGJ are the distal ends of (1) squamous epithelium, (2) deep esophageal glands and ducts, and (3) multilayered epithelium.
Histologically, the mucosal EGJ should be defined as the most distal ends of squamous epithelium and deep esophageal glands and ducts.
Srivastava et al (32) evaluated mucosal biopsy samples from 20 patients with Barrett esophagus and 20 patients with intestinal metaplasia of the gastric cardia; they found that intestinal metaplasia subjacent to squamous epithelium, intestinal metaplasia confined to the superficial mucosa, and presence of esophageal glands or ducts were only seen in samples from patients with Barrett esophagus (with sensitivity of 57%, 40%, and 30%, respectively).