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eserine

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eserine

physostigmine 
A reversible anticholinesterase drug used as a parasympathomimetic which, when used in the eye constricts the pupil. It may be used in solution of 0.25-1% or ointment 0.25-0.50% in the treatment of glaucoma, but because of its side-effects its usage is rare nowadays. It is sometimes combined with pilocarpine. Syn. eserine. See miotics; neostigmine; parasympathomimetic drug.


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A cholinesterase inhibitor, in this case eserine sulfate, is also necessary for specificity.
We added eserine sulfate to four of the test tubes to determine noncholinesterase-mediated hydrolysis of acetylthiocholine (ATCh) iodide.
Eserine [(3 [Alpha],S-[Alpha])-1,2,3,3 [Alpha],8,8 [Alpha]-Hexahydro-1,3 [Alpha],8-trimethylpyrrolo (2,3-b) indol-5-ol methylcarbamate] is an ester obtained from calabar beans, the seeds of the vine Physostigma venenosum.
 
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