escape mutation


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escape mutation

The ability of a microorganism to defend itself from host immune responses by making mutations in its genotype and phenotype. Organisms with a high rate of mutations, e.g., human immunodeficiency virus, rely on mutational escape as one mechanism to avoid destruction by host cells.
Synonym: mutational escape
See also: mutation
References in periodicals archive ?
Kaslow said that his team's work showed how efficiently the virus evolves escape mutations that help infected cells avoid destruction.
The vaccines would have to be redesigned to recognize VEMs and incorporate hepatitis B virus proteins that aren't vulnerable to escape mutations, he added.
The advantage of targeting cellular factors is that they are far less mutable than HIV proteins and therefore less likely to have escape mutations.