erythropoietin


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erythropoietin

 [ĕ-rith″ro-poi´ĕ-tin]
a glycoprotein hormone secreted by the kidney in the adult and by the liver in the fetus, which acts on stem cells of the bone marrow to stimulate red blood cell production (erythropoiesis).
recombinant human erythropoietin epoetin.

e·ryth·ro·poi·e·tin (EPO),

(ĕ-rith'rō-poy'ĕ-tin), [MIM*133170]
A protein containing sialic acid that enhances erythropoiesis by stimulating formation of proerythroblasts and release of reticulocytes from bone marrow; it is formed by the kidney and liver, and possibly by other tissues, and can be detected in human plasma and urine.

erythropoietin

/eryth·ro·poi·e·tin/ (-poi´ĕ-tin) a glycoprotein hormone secreted by the kidney in the adult and by the liver in the fetus, which acts on stem cells of the bone marrow to stimulate red blood cell production (erythropoiesis).
recombinant human erythropoietin  (r-HuEPO) epoetin.

erythropoietin

(ĭ-rĭth′rō-poi-ē′tĭn)
n.
1. A glycoprotein hormone that stimulates the production of red blood cells by stem cells in bone marrow. Produced mainly by the kidneys, it is released in response to decreased levels of oxygen in body tissue.
2. Epoetin alfa.

erythropoietin (EPO)

[erith′rōpō·ē′tin]
Etymology: Gk, erythros + poiein, to make
a glycoprotein hormone synthesized mainly in the kidneys and released into the bloodstream in response to anoxia. The hormone acts to stimulate and to regulate the production of erythrocytes and thus increases the oxygen-carrying capacity of the blood. See also erythropoiesis.

EPO

A gene on chromosome 7q22 that encodes erythropoietin, a secreted, glycosylated cytokine found in the plasma, which regulates red cell production by promoting erythroid differentiation and initiating haemoglobin synthesis. Erythropoietin plays a neuroprotective role in response to brain injury and is antiapoptotic.

Molecular pathology
Genetic variability of EPO has been linked to microvascular complications of diabetes type 2, including diabetic retinopathy, nephropathy leading to end-stage renal disease, and neuropathy

erythropoietin

EPO Physiology A 46 kD glycoprotein colony-stimulating factor produced predominantly by cells adjacent to the proximal renal tubules in response to signals from an oxygen-sensitive substances in the kidneys–eg, heme Adverse effects Chest pain, swelling, tachycardia, headache, HTN; erythropoietin–EP binds to receptors in erythroid precursors that mature into RBCs; EP is ↑ by hypoxia or by ectopic production from tumors–eg, cerebellar hemangioblastoma, hepatoma, pheochromocytoma, uterine leiomyoma, and renal cell carcinoma; it may not be ↑ in anemic premature infants, and is ↓ in 2º anemia, chronic inflammation, P vera, and certain CAs and may be useful in myeloma-related anemia; EP therapy is indicated for HIV-related anemia, anemia of renal failure and prematurity; it ↑ number of units of autologous RBCs that may be donated before surgery, for ↑ number of units that may be phlebotomized in Pts with hemochromatosis and to ↑ units that may be drawn from a person with a rare blood type

e·ryth·ro·poi·e·tin

(ĕ-rith'rō-poy'ĕ-tin)
A protein that enhances erythropoiesis by stimulating formation of proerythroblasts and releasing reticulocytes from bone marrow; secreted mainly by the kidney and possibly by other tissues.

Erythropoietin

A hormone produced by the kidneys that stimulates the production of red blood cells by bone marrow.
Mentioned in: Dialysis, Kidney

erythropoietin

kidney-derived protein promoting erythrocyte formation within bone marrow

erythropoietin

a glycoprotein hormone secreted mainly by the kidney. A profactor, erythropoietinogen, is first produced in the liver, transferred to the kidney and converted to active erythropoietin in the kidney. The erythropoietin acts on stem cells of the bone marrow to stimulate red blood cell production (erythropoiesis). Called also erythropoietin stimulating factor, erythrogenin.

recombinant erythropoietin
used to treat dogs and cats with nonregenerative anemia of renal disease; animals develop antibodies to the human product.
erythropoietin stimulating factor
see erythropoietin (above).
References in periodicals archive ?
Erythropoietin attenuates renal injury in experimental acute renal failure ischaemic/reperfusion model.
Clinical trials of erythropoietin in acute kidney injury
Recombinant human erythropoietin in anemic patients with end-stage renal disease: Results of a phase III multicenter clinical trial.
Erythropoietin, for example, represents a multi-billion-dollar global market, with sales in Europe of approximately US$1.
Explanations for the decrease in the number of transfusions include limiting the volume of blood tests, the utilization of a smaller volume of blood to perform these tests, the use of noninvasive means of assessing oxygenation and ventilation (pulse oximetry and transcutaneous monitoring), the use of erythropoietin therapy, and the adoption of various restricted transfusion criteria.
The success of erythropoietin therapy depends on an adequate amount of transferrinbound iron, so adjunctive iron is usually given orally, if there's time, or parenterally.
Today, erythropoietin therapy is a standard treatment for Jehovah's Witnesses and others who feel uncomfortable about transfusions.
Current Methods for Detecting Antibodies against Erythropoietin and Other Recombinant Proteins
Initial studies on this use of erythropoietin are now underway at Case Western Reserve University in Cleveland, where high doses of the hormone have been found to increase the average blood predonation from 4 units to 5.

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