Erythropoietin is a glycoprotein hormone that regulates erythroid cell
proliferation in bone marrow response to tissue hypoxia.
Since the receptor for B19 is blood group 'P' antigen (tetrahexose ceramide), it has great tropism for erythroid cell
precursors in the bone marrow.
Of note was the concurrent moderate decrease in PCV (30%, down from previous measurement of 40%) indicating that the erythroid cell
line was also affected.
The bone marrow in CNL is hypercellular and myeloid, and usually has an myeloid to erythroid cell
ratio that varies between 5:1 and 25:1 (normal ratios are 2:1 to 5:1).
LG5640 increased erythroid cell
viability with partial efficacy to rHuEPO.
Bone marrow biopsy showed evidence of moderate hyperplasia of the erythroid cell
line (Figure 2).
The KG-1a, Kasumi-1, THP-1, U-937, and HL60 human myeloid lines; the Raji and Daudi B-cell lines; the Jurkat and CCRF-CEM T-cell lines; and the K562 and UT7 erythroid cell
lines were obtained from the cell bank of Tohoku University.
The background myeloid and erythroid cell
lines were present and maturing.
Transferrin receptors and iron uptake during erythroid cell
Clonal Analysis of Human Bone Marrow CD34+ Cells Edited by BCL11A-Targeting ZFNs Reveals Clinically Relevant Levels of Gamma Globin Expression in Edited Erythroid Cells
-- Abstract #3234 Session: 801.
1 g in humans) is distributed in the hemoglobin of red blood cells and developing erythroid cells
and serves in oxygen transport.
4] Activation of androgen receptors in erythroid cells
appears to be necessary for testosterone to develop an erythropoietic effect in the bone marrow.