The bone marrow in hypothyroidism in absence of associated deficiency of iron or vit B12 usually shows decreased cellularity and increased fat content without evidence of erythroid
AG, the extract of Angelica gigas treatment; HO-1, heme oxygenase-1; Nrf2, nuclear factor erythroid
2-related factor 2.
4-6) When HPV B19 infects the bone marrow erythroid
cells of these patients, decompensation occurs and thus the patient presents with signs and symptoms of abrupt onset severe anemia.
5 g/dl, RET 28 x 10 [sup]9 /L; bone marrow smear showed mature lymphocytes of 21%, granulocytic cells 71%; erythroid
cells 7% and M/E ratio 10.
Identification of erythroferrone as an erythroid
regulator of iron metabolism.
6] The alteration of myeloid and erythroid
ratio in our patient supports this hypothesis.
Global regulation of erythroid
gene expression by transcription factor GATA-1.
Moreover, human bone marrow CD34+ hematopoietic progenitors drawn from [beta]-thalassemia patients and primary erythroid
progenitors stem cells (EPSCs) obtained from peripheral blood are also great in vitro models to study the effect of different HbF-inducing agents [1,13].
Hematopoietic cells include a diverse set of cell types, including erythroid
cells (red blood cells), lymphocytes (white blood cells), and myelocytes (bone marrow cells).
While not always statistically significant, certain features were more common in CVD than in the control group (Figure), including (1) abnormal bony trabeculae, (2) megaloblastoid changes in the erythroid
lineage, (3) sea-blue histiocytes (SBHs), and (4) ALIP of the granulocytic lineage.
Inthebonemarrowbiopsy, 30% cellularity, a small number of micromegakaryocytes, decreased erythroid
and myeloid series elements, significantly increased eosinophilic precursors, and hypocellularity were observed, but there was no increase in the blastic series (Figure 1).
Histology revealed the mass to be composed of mature hemopoetic elements, with a predominance of erythroid