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erythrodysesthesia

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erythrodysesthesia


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5) While most commonly associated with chemotherapy agent toxicity, palmar/plantar erythrodysesthesia (PPE) or hand-foot syndrome (HFS) was initially described in association with sickle cell [beta]-thalassemia (13,14,15) and subsequently with sickle cell crisis.
The most frequently occurring Grade 3 and Grade 4 adverse events (>5%) regardless of relationship to drug were: fatigue, headache, palmar-plantar erythrodysesthesia, confusional state, alanine aminotransferase increase, convulsion, lymphopenia, hypophosphatemia, lipase increase, diarrhea, aspartate aminotransferase increase, and gait disturbance.
Adverse events of special interest were: hypertension (all incidences, 39%; Grade 3/4, 7%), palmar-plantar erythrodysesthesia (30%; 7%), bleeding events (28%; 9%), proteinuria (26%; 0%), pulmonary embolism (9%; 7%) and craniotomy wound dehiscence (4%; 2%).
 
 
 
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