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erythema nodosum leprosum |
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erythema /er·y·the·ma/ (er″ĭ-the´mah) redness of the skin due to congestion of the capillaries.erythem´atouserythe´mic erythema annula´re a type of erythema multiforme with ring-shaped lesions. erythema annula´re centri´fugum a chronic variant of erythema multiforme usually affecting the thighs and lower legs, with single or multiple erythematous-edematous papules that enlarge peripherally and clear in the center to produce annular lesions that may coalesce. erythema chro´nicum mi´grans an annular erythema due to the bite of a tick (Ixodes); it begins as an erythematous plaque several weeks after the bite and spreads peripherally with central clearing. See also Lyme disease, under disease. cold erythema a congenital hypersensitivity to cold seen in children, characterized by localized pain, widespread erythema, occasional muscle spasms, and vascular collapse on exposure to cold, and vomiting after drinking cold liquids. epidemic arthritic erythema Haverhill fever. erythema indura´tum chronic necrotizing vasculitis, usually occurring on the calves of young women; its association with tuberculosis is in dispute. erythema infectio´sum a mildly contagious, sometimes epidemic, disease of children between the ages of four and twelve, marked by a rose-colored, coarsely lacelike macular rash and caused by human parvovirus B19. erythema i´ris a type of erythema multiforme in which the lesions form concentric rings, producing a target-like appearance. erythema margina´tum a type of erythema multiforme in which the reddened areas are disk-shaped with elevated edges. erythema mi´grans erythema multifor´me a symptom complex with highly polymorphic skin lesions, including macular papules, vesicles, and bullae; attacks are usually self-limited but recurrences are the rule. erythema nodo´sum an acute inflammatory skin disease marked by tender red nodules, usually on the shins, due to exudation of blood and serum. erythema nodo´sum lepro´sum a form of lepra reaction occurring in lepromatous and sometimes borderline leprosy, marked by the occurrence of tender, inflamed subcutaneous nodules; the reactions resemble multifocal Arthus reactions. toxic erythema , erythema tox´icum a generalized erythematous or erythematomacular eruption due to administration of a drug or to bacterial toxins or other toxic substances. erythema tox´icum neonato´rum a self-limited urticarial condition affecting infants in the first few days of life.
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The FDA's announcement Monday came just two weeks after a panel of outside scientific advisers voted 8-2 to recommend that the agency approve the drug for patients with erythema nodosum leprosum, or ENL, a complication of leprosy that causes skin lesions, fever and other symptoms. Food and Drug Administration (FDA) clearance on July 16, 1998 for the acute treatment of cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL) and as maintenance therapy for prevention and suppression of cutaneous manifestation recurrences. Food and Drug Administration (FDA) clearance on July 16, 1998 for the acute treatment of cutaneous manifestations of moderate to severe erythema nodosum leprosum (ENL) and as maintenance therapy for prevention and suppression of cutaneous manifestation recurrences. |
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