erm gene

erm gene

(ŭrm) [Acronym fm. erythromycin ribosomal methylase]
A gene that promotes methylation of ribosomal RNA and other intracellular molecules. It is responsible for bacterial resistance to antibiotics such as the macrolides, lincosamides, and streptogramins.
References in periodicals archive ?
massiliense by hsp65 PCR and erm gene sequencing (4) and 14-day susceptibility to clarithromycin (10).
Therefore, we hypothesized that either mutations in the erm gene promoter region have upregulated methylase expression or that mutations in the coding region have changed the methylase specificity to include the additional binding sites of telithromycin.
Erm genes permanently alter ribosomes causing an inability of the macrolides to bind, thus inhibiting the drug's action.
Macrolide resistance in Streptococcus pyogenes results primarily from modification of the drug target site by methyltransferases encoded by erm genes, erm(A) and erm(B) or by active efflux mediated by a mef-encoded efflux pump.