ergot alkaloid

ergot alkaloid

one of a large group of alkaloids derived from a common fungus, Claviceps purpurea. The alkaloids comprise three groups: the amino acid alkaloids typified by ergotamine, the dihydrogenated amino acid alkaloids such as dihydroergotamine, and the amine alkaloids such as ergonovine.
indications Ergotamine and dihydroergotamine are less effective oxytocics than ergonovine. Therefore ergonovine, given orally or intravenously, is currently used in obstetrics to treat or prevent postpartum uterine atony and to complete an incomplete or missed abortion. Ergotamine is prescribed to relieve migraine headache. It acts by reducing the amplitude of arterial pulsations in the external carotid branches of the cranial arteries resulting from stimulation of vasoconstrictive alpha receptors, and it may also act as a serotonin antagonist. See also missed abortion.
contraindications Peripheral vascular disease, coronary artery disease, hypertension, renal or hepatic dysfunction, and sepsis are contraindications for ergot alkaloids. Pregnancy prohibits their use because they may cause contractions of the uterus, decreased blood flow to the fetus, and fetal death.
adverse effects Ergot poisoning may result from prolonged or excessive use of the drug or accidental ingestion of contaminated grain. Signs of toxicity are thirst, diarrhea, dizziness, chest pain, abnormal and variable rate of cardiac contraction, nausea and vomiting, digital paresthesia, severe cramping, and seizures. Tissue anoxia and gangrene of the extremities may occur as a result of prolonged vasoconstriction if poisoning is severe.
References in periodicals archive ?
Triptan and ergot alkaloid medications are the two main migraine-specific treatments.
Ergot alkaloid toxicity has not yet been demonstrated, but potential nutritional and economic losses could have substantial impact on public health.
This fungus imparts hardiness to the plant, but it also produces ergot alkaloid toxins that cause fescue toxicosis in grazing animals.
Bromocriptine is a semisynthetic ergot alkaloid that binds to receptors on normal and tumor lactotrophs and inhibits the synthesis and secretion of prolactin.
Ergot alkaloid preparations are contraindicated in pregnancy because of dose-related developmental toxicity and oxytocic properties.
Ergot alkaloid preparations are contraindicated in pregnancy because of their dose-related developmental toxicity and oxytocic properties.
During postmarketing surveillance of patients taking Permax, "a small number of patients" developed aortic, mitral, and/or tricuspid valvulopathy "consistent with that associated with carcinoid syndrome and the use of other ergot alkaloid drugs.
The Company has recently completed studies as part of two Phase 2 clinical development programs involving a proprietary formulation of nebulized budesonide for the potential treatment of children with asthma, and a proprietary formulation of an inhaled ergot alkaloid delivered by the Company's proprietary Tempo Inhaler, for the potential treatment of migraines.
The Company has two Phase 2 clinical development programs: a proprietary formulation of nebulized budesonide for the potential treatment of children with asthma, and a proprietary formulation of an inhaled ergot alkaloid for the potential treatment of migraines.
The Global Migraine Drugs market can be divided into two segments: Selective Serotonin Receptor (5- HTI) Agonists/ Triptans and Ergot Alkaloids.
Drug Interactions: Co-administration of cisapride, pimozide, quinidine, dofetilide, levacetylmethadol (levomethadyl), felodipine, oral midazolam, nisoldipine, triazolam, lovastatin, simvastatin, ergot alkaloids such as dihydroergotamine, ergometrine (ergonovine), ergotamine and methylergometrine (methylergonovine) or methadone with ONMEL[TM] is contraindicated.