epoprostenol


Also found in: Dictionary, Wikipedia.
Related to epoprostenol: alprostadil, Bosentan, Epoprostenol sodium

epoprostenol

 [e″po-pros´tĕ-nol]
name for prostacyclin when used pharmaceutically; it is used in the form of the sodium salt as an inhibitor of platelet aggregation for blood contacting nonbiological systems, as in renal dialysis, as a pulmonary antihypertensive, and as a vasodilator.

pros·ta·cy·clin

(pros'tă-sī'klin),
A potent natural inhibitor of platelet aggregation and a powerful vasodilator.

epoprostenol

/ep·o·pro·sten·ol/ (e″po-pros´tĕ-nol) name for prostacyclin when used pharmaceutically; used in the form of the sodium salt as an inhibitor of platelet aggregation when blood contacts nonbiological systems, a pulmonary antihypertensive, and a vasodilator.

epoprostenol

[e′popros′tĕnol]
name for prostacyclin when used pharmaceutically. It is used in the form of the sodium salt as an inhibitor of platelet aggregation for blood contacting nonbiological systems, as in renal dialysis; as a pulmonary antihypertensive; and as a vasodilator.

Beraprost

An oral prostacyclin PGI2 analogue with vasodilator, antiplatelet, and cytoprotective effects, used to manage pulmonary arterial hypertension. Beraprost improves exercise capacity and symptoms in NYHA-functional class-II and -III patients with PAH and, in particular, in those with primary pulmonary hypertension.

Adverse effects
Headache, facial flushing, vasodilation.

epoprostenol

Prostacyclin. A powerful inhibitor of clumping of blood platelets and thus of blood clotting. It is used with heart-lung (cardiopulmonary bypass) machines and artificial kidneys (dialysis machines) to preserve the platelets in the blood being pumped through them. Epoprostenol also widens (dilates) arteries. A brand name is Flotan.

epoprostenol

References in periodicals archive ?
A comparison of continuous intravenous epoprostenol (prostacyclin) with conventional therapy for primary pulmonary hypertension.
Nick Ainger, formerly a Wales Office Minister, said back in 1999 that a child in his constituency was being treated with the drug Epoprostenol for a heart condition, at an annual cost of pounds 120,000.
NEWBURY, England, March 3 /PRNewswire/ -- The National Institute for Clinical Excellence (NICE) has today published on its website the preliminary recommendations of its Appraisal Committee on the use of epoprostenol, iloprost, bosentan, sitaxentan and sildenafil for the treatment of pulmonary hypertension in adults.
Continuous infusion of epoprostenol improves the net balance between pulmonary endothelin-1 clearance and release in primary pulmonary hypertension.
33) IV epoprostenol appears to have the best effects in this regard.
Prostanoid therapies currently licensed by the FDA include epoprostenol, for continuous intravenous infusion; treprostinil, for continuous subcutaneous and intravenous infusion; and iloprost, for inhalation.
A drug called epoprostenol, combined with potent combination HIV therapy, may improve survival in those patients with PAH.
Although some patients may respond to oral calcium channel blockers, such as nifedipine and diltiazem, for relief of symptoms (Gaine, 2000), those with more severe disease may need a continuous intravenous infusion of a vasodilatory agent such as epoprostenol (Flolan).
A new study by McLaughlin and her colleagues finds that the drug prostacyclin, also called epoprostenol, may be a powerful weapon against this disease.
Treprostinil indications: Treatment of pulmonary arterial hypertension, optionally in patients requiring transition from Epoprostenol
One exception to this may be the use of intravenous epoprostenol, which led to significant improvements in symptoms, exercise capacity, quality of life, cardiopulmonary hemodynamics, and survival without significant development of pulmonary edema in a few studies of patients with PVOD (8).