epoetin


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epoetin

 [e-po´ĕ-tin]
a form of human erythropoietin produced by recombinant technology and having the same amino acid sequence and mechanism of action as endogenous erythropoietin. Used in treatment of anemia from various causes, including chronic renal failure, zidovudine therapy, and cancer chemotherapy; also used prior to surgery in anemic patients to reduce the need for blood transfusion. Administered intravenously or subcutaneously. It is available in two forms, designated epoetin alfa (the form used in the United States) and epoetin beta (used in various other countries). Called also recombinant human erythropoietin.

epoetin

/epo·e·tin/ (e-po´ĕ-tin) a recombinant form of human erythropoietin, used as an antianemic; in the United States the form used is e. alfa but e. beta may be used elsewhere.

EPO

A gene on chromosome 7q22 that encodes erythropoietin, a secreted, glycosylated cytokine found in the plasma, which regulates red cell production by promoting erythroid differentiation and initiating haemoglobin synthesis. Erythropoietin plays a neuroprotective role in response to brain injury and is antiapoptotic.

Molecular pathology
Genetic variability of EPO has been linked to microvascular complications of diabetes type 2, including diabetic retinopathy, nephropathy leading to end-stage renal disease, and neuropathy

epoetin

Human erythopoetin made by genetic engineering for use as a drug to treat severe anaemia Brand names are Eprex and Neorecormon.
References in periodicals archive ?
The primary efficacy endpoint, the mean change in hemoglobin (Hb) from baseline, in each of the four Phase 3 studies (EMERALD 1, EMERALD 2, PEARL 1 and PEARL 2) met the statistical criteria for non-inferiority, when Hematide was compared to epoetin and darbepoetin, in correcting and/or maintaining Hb in the target range.
Poster 188, Sunday 31st October 2004, 09:00 - 17:00, Breast cancer advanced session: Once weekly epoetin beta in patients with metastatic breast cancer receiving anthracycline- or taxane-based chemotherapy.
GOG-191 was a randomized phase III trial designed to evaluate the efficacy of maintaining hemoglobin levels above 12 grams per deciliter of blood (g/dL) with Epoetin alfa in subjects with advanced cervical cancer undergoing chemoradiotherapy.
Ortho Biotech is the Biopharmaceutical division of Janssen-Cilag, and markets epoetin alfa, a recombinant human erythropoietin, as EPREX(R)/ERYPO(R) (epoetin alfa) in Europe.
Depending on the country in which Epoetin alfa is marketed, these indications may differ.
Biosimilar epoetin alpha has already launched in Europe and will enter the US and Japan from 2013 54
Both studies are consistent with the assessment of biosimilarity between the reference product, EPOGEN, and the Hospira proposed biosimilar, Epoetin Hospira," said Stan Bukofzer, M.
The analyses first modeled the facility use of epoetin and other injectable drugs with cubic splines (with knots located at the 5th, 25th, 50th, 75th, and 95th percentiles).
Darbepoetin alfa, marketed as Arandesp, and epoetin alfa, marketed as Epogen o and Procrit, are the ESAs approved in the United States; they are administered as often as one to three times per week.
In April 2008, the MRP converted all HD patients from epoetin alfa MDV to epoetin alfa pre-filled safety needle syringes (PFS).
MIRCERA is the only drug to have compared itself in its registration program to three ESAs: epoetin alfa, beta and darbepoetin alfa.