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epoetin

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epoetin /epo·e·tin/ (e-po´ĕ-tin) a recombinant form of human erythropoietin, used as an antianemic; in the United States the form used is e. alfa but e. beta may be used elsewhere.
epoetin [e-po´ĕ-tin]
a form of human erythropoietin produced by recombinant technology and having the same amino acid sequence and mechanism of action as endogenous erythropoietin. Used in treatment of anemia from various causes, including chronic renal failure, zidovudine therapy, and cancer chemotherapy; also used prior to surgery in anemic patients to reduce the need for blood transfusion. Administered intravenously or subcutaneously. It is available in two forms, designated epoetin alfa (the form used in the United States) and epoetin beta (used in various other countries). Called also recombinant human erythropoietin.


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The CHMP proposal includes amending the summaries of product characteristics for all approved ESAs to stipulate a uniform target hemoglobin range for all epoetins with guidance to avoid sustained hemoglobin levels above 12 g/dL and providing guidance for dosage adjustments to maintain hemoglobin concentration between 10-12 g/dL.
Thousand Oaks, CA) and Johnson & Johnson (New Brunswick, NJ) with their respective brands of epoetin alfa (Amgen's Epogen and Johnson & Johnson's Procrit/Eprex).
The European Agency for the Evaluation of Medicinal Products has already developed draft guidelines for generic versions of insulin, human growth factor, epoetin and colony stimulating factors (CSFs).
 
 
 
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