epitope


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determinant

 [de-ter´mĭ-nant]
a factor that establishes the nature of an entity or event.
antigenic determinant a site on the surface of an antigen molecule to which a single antibody molecule binds; generally an antigen has several or many different antigenic determinants and reacts with many different antibodies. Called also epitope.
 Antigens contain antigenic determinants (epitopes) and antibodies contain antibody combining sites (paratopes). From Copstead and Banasik, 2000.
hidden determinant an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
immunogenic determinant the part of an immunogenic molecule that interacts with a helper T cell in triggering antibody production as opposed to the antigenic determinant or hapten, which interacts with B cells.

ep·i·tope

(ep'i-tōp),
The simplest form of an antigenic determinant on a complex antigenic molecule, which can combine with antibody or T cell receptor.
[epi- + -tope]

epitope

/ep·i·tope/ (ep´ĭ-tōp) an antigenic determinant (see under determinant ) of known structure.

epitope

(ĕp′ĭ-tōp′)
n.
A localized region on the surface of an antigen capable of eliciting an immune response and of combining with a specific antibody to counter that response.

epitope

[ep′itōp]
Etymology: Gk epi + topos, place

epitope

Any site on a biomolecule (antigenic determinant) which can evoke antibody formation. The minimum size of a molecule capable of evoking antibody formation is about 1 kD; if the molecule is smaller, as with haptens, it may evoke an immune response by associating with a carrier protein. Large non-polymeric molecules can have many epitopes. When the van der Waals surfaces of proteins are constructed by X-ray crystallography, epitopic sites appear to require prominently exposed regions—“hills” and “ridges” with surface rigidity. More flexible sites are less antigenic.

epitope

Immunology Any site on a molecule–an antigenic determinant that can evoke antibody formation. See Idiotype, Immunogenicity.

ep·i·tope

(ep'i-tōp)
The simplest form of an antigenic determinant, on a complex antigenic molecule, that can combine with antibody or T-cell receptor.

epitope

An immunologically active discrete site on an ANTIGEN to which an ANTIBODY or a B or T cell receptor actually binds. See also LINEAR EPITOPE and CONFORMATIONAL EPITOPE.

epitope

an antigenic determinant which interacts with an IMMUNOGLOBULIN or T-CELL receptor.

epitope

protein residue at the surface of a microorganism or non-self cell; triggers host immune response

epitope

see antigenic determinant.

continuous epitope
contiguous amino acid sequences in a linear array.
discontinuous epitope
one in which amino acids are in close proximity in the folded protein, but distant when unfolded.
References in periodicals archive ?
Measurement of B-type natri uretic peptide by two assays utilizing antibodies with different epitope specificity.
The immune-dominant epitopes were identified within the bovine RVA VP6 protein by Protean software implemented in DNA STAR using various predictive algorithms.
The authors found that similar immunoglobulin epitopes on allergenic proteins, as defined by SDAP, could account for some of the cross-reactivity between peanuts and tree nuts.
HLA selection and epitope prediction of A(H1N1)pdm09 surface glycoproteins Epitopes were predicted against selected alleles of 10 MHC I Supertypes (A2, A3, B7, B15, A24, B44, B57, ABX, B27 and BX) and 8 MHC II alleles of Supertype DRB1 that covers 99% Asian population (De Groot et al.
Variable epitope libraries: new vaccine immunogens capable of inducing broad human immunodeficiency virus type 1-neutralizing antibody response.
Then, they used the mix to find unknown epitopes for portions of the influenza virus that causes avian flu and for the parasite involved in malaria.
For MHC class II antigen-restricted epitopes essential for antibody and Th1 responses, HA of pandemic (H1N1) 2009 virus contains HLA-DRA*0101/DRB1 *0101-restricted SVIEKMNTQFTAV (5), as well as HLA-DRA*0101/ DRB1*0401-restricted EKMNTQFTAVGKE, TGLRNIPSIQSRG, and ELLVLLENERTLDY (5), and HLADRB5* 0101-restricted DYEELREQL SSVSSFERFE (5) epitopes.
Once provoked from its slumber by this autoantigenic structure into responding, the autoimmune response expands to involve other structures of the autoantigen, a process known as "B cell epitope spreading" (reviewed in Harley and James (6) and Schlomchik et al (9)).
These results demonstrate that protein structure plays an important role in the stability of this allergen to resist digestion and provide a link between food allergen structure, stability to digestion, and the immunodominant IgE-binding epitopes within a population of food-allergic individuals.
A useful approach may involve the use of an expression library, whereby the genome of a pathogen is fragmented and the pieces of DNA captured to create a pathogen library that represents most of the T cell epitopes that exist for that pathogen.
Se sintetizaron peptidos lineales y con restriccion conformacional a bucle para determinar cual imitaba mejor el epitope presente en la proteina Pfs25.