epitope


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determinant

 [de-ter´mĭ-nant]
a factor that establishes the nature of an entity or event.
antigenic determinant a site on the surface of an antigen molecule to which a single antibody molecule binds; generally an antigen has several or many different antigenic determinants and reacts with many different antibodies. Called also epitope.
 Antigens contain antigenic determinants (epitopes) and antibodies contain antibody combining sites (paratopes). From Copstead and Banasik, 2000.
hidden determinant an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
immunogenic determinant the part of an immunogenic molecule that interacts with a helper T cell in triggering antibody production as opposed to the antigenic determinant or hapten, which interacts with B cells.

ep·i·tope

(ep'i-tōp),
The simplest form of an antigenic determinant on a complex antigenic molecule, which can combine with antibody or T cell receptor.
[epi- + -tope]

epitope

/ep·i·tope/ (ep´ĭ-tōp) an antigenic determinant (see under determinant ) of known structure.

epitope

(ĕp′ĭ-tōp′)
n.
A localized region on the surface of an antigen capable of eliciting an immune response and of combining with a specific antibody to counter that response.

epitope

[ep′itōp]
Etymology: Gk epi + topos, place

epitope

Any site on a biomolecule (antigenic determinant) which can evoke antibody formation. The minimum size of a molecule capable of evoking antibody formation is about 1 kD; if the molecule is smaller, as with haptens, it may evoke an immune response by associating with a carrier protein. Large non-polymeric molecules can have many epitopes. When the van der Waals surfaces of proteins are constructed by X-ray crystallography, epitopic sites appear to require prominently exposed regions—“hills” and “ridges” with surface rigidity. More flexible sites are less antigenic.

epitope

Immunology Any site on a molecule–an antigenic determinant that can evoke antibody formation. See Idiotype, Immunogenicity.

ep·i·tope

(ep'i-tōp)
The simplest form of an antigenic determinant, on a complex antigenic molecule, that can combine with antibody or T-cell receptor.

epitope

An immunologically active discrete site on an ANTIGEN to which an ANTIBODY or a B or T cell receptor actually binds. See also LINEAR EPITOPE and CONFORMATIONAL EPITOPE.

epitope

an antigenic determinant which interacts with an IMMUNOGLOBULIN or T-CELL receptor.

epitope

protein residue at the surface of a microorganism or non-self cell; triggers host immune response

epitope

see antigenic determinant.

continuous epitope
contiguous amino acid sequences in a linear array.
discontinuous epitope
one in which amino acids are in close proximity in the folded protein, but distant when unfolded.
References in periodicals archive ?
A drop of human blood is presumed to have 10e11 specific antibodies that recognize different immunogens (natural antigen epitopes and antigenic mimics, mimotopes).
In contrast, 8I-7 did not recognize peptide 135-152, which contains the 137-148 epitope of 8I-7 (as stated by the manufacturer), but it did recognize a peptide comprising residues 161-178 (Fig.
After extracting the epitope from the virus, the researchers transplanted the epitope onto a protein with a complementary structure that acted as the scaffold.
The following results were obtained using direct ELISPOT: * 2/32 (6%) of vaccine recipients responded to 2 or more epitopes * 5/32 (15%) of vaccine recipients responded to 1 or more epitopes * Restimulated ELISPOT: After blood draws, the PBMC are incubated in vitro for seven days with a pool of the 21 vaccine epitopes prior to detecting the epitope-specific CTL.
The primary neutralization epitope of porcine reproductive and respiratory syndrome virus is located in the middle of the GP5 ectodomain.
Identification and mutational analysis of the immunodominant IgE binding epitopes of the major peanut allergen Ara h2.
Fairly strong responses were seen in the genomic areas coding for the immunodominant epitopes gag, pol, and env.
We determined epitope recognition by TgAb in sera from patients with a competitive ELISA as described previously (14).
Emile Loria, President and CEO of Epimmune said, "The Phase 1 results clearly demonstrate the ability of our proprietary analog epitopes included in EP-2101 to elicit a multi-epitope response in a cancer setting where breaking tolerance has always been a key challenge.
Epitope mapping of neutralizing botulinum neurotoxin A antibodies by phage display.
Williamson, the president and chief executive officer of A&W, resigned Wednesday amid the controversy, according to Epitope officials.
This is the second NIH award recently received by Integral Molecular for epitope mapping services.