It is usually a chronic inflammatory changes to the epithelial rest of malasses in the periodontium of the affected teeth.
1 It is usually a chronic inflammatory change to the epithelial rest of malasses in the periodontium of the affected teeth.
INTRODUCTION: Ameloblastomas are benign locally aggressive, polymorphic neoplasms of proliferating odontogenic epithelial origin, arising from cell rests of enamel organ, either remnants of dental lamina or remnants of Hertwig's sheaths, the epithelial rest
of Malassez, the developing enamel organ, basal cell epithelium of the jaws.
Yamawaki K, Matsuzaka K, Kokubu E, Inoue T Effects of epidermal growth factor and/or nerve growth factor on Malassez's epithelial rest cells in vitro: expression of mRNA for osteopontin, bone morphogenetic protein 2 and vascular endothelial growth factor J Periodontal Res 2010; 45(3): 421-427
However, since the epithelial rests of Malassez are embedded in the periodontal ligament, consequently making it difficult to isolate and/or manipulate Malassez epithelium both in vitro and in vivo, no firm evidence has been obtained to support their functional role.
2) Cystic transformation occurs owing to inflammatory stimulation of the epithelial rests
of Malassez in the periodontal ligament, secondary to a root canal infection, in which the bacteria and their products, that were previously confined to the dental pulp, go beyond the root canal system and reach the periapical tissues.
Congenital dermoid cysts arise from epithelial rests
trapped during midline fusion of these branchial arches whereas acquired dermoid cyst arise from epithelium implanted during trauma and they occur at the sites away from midline.
2] The cases reported in association with embedded teeth indicate the tumor may also develop from proliferation of epithelial rests
in the dental follicle.
Petrous apex cholesteatoma, which is believed to arise from congenital epithelial rests
, can lead to the accumulation of epithelial cells.