epirubicin


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epirubicin

 [ep″e-roo´bĭ-sin]
an antitumor antibiotic of the anthracycline group, having the same actions as doxorubicin but a lower toxicity; administered intravenously in the treatment of carcinoma of the breast, ovary, stomach, colon, and rectum, as well as leukemia, lymphoma, and multiple myeloma.

epirubicin

/epi·ru·bi·cin/ (-roo´bĭ-sin) an antineoplastic with action similar to doxorubicin; used in the treatment of various carcinomas, leukemia, lymphoma, and multiple myeloma.

epirubicin

an antibiotic antineoplastic.
indications It is used as an adjuvant therapy to treat breast cancer with axillary node involvement following resection.
contraindications Factors that prohibit its use include severe hepatic disease, baseline neutrophil count less than 1500 cells/mm3, severe myocardial insufficiency, recent myocardial infarction, pregnancy, lactation, systemic infections, and known hypersensitivity to this drug, anthracyclines, or anthracenediones.
adverse effects Life-threatening effects are thrombocytopenia, leukopenia, anemia, neutropenia, secondary acute myelocytic leukemia, sinus tachycardia, premature ventricular contractions, bradycardia, and extrasystoles. Other serious adverse effects include increased blood pressure and chest pain. Common side effects include nausea, vomiting, anorexia, mucositis, diarrhea, amenorrhea, hot flashes, hyperuricemia, rash, necrosis at the injection site, reversible alopecia, infection, febrile neutropenia, lethargy, fever, and conjunctivitis.

epirubicin

A CYTOTOXIC anti-cancer drug. A brand name is Pharmorubicin.

epirubicin

an anthracycline antibiotic similar to doxorubicin, used as an antineoplastic agent.
References in periodicals archive ?
We introduced single immediate instillation of 50 mg epirubicin following TUR-BT for all cases in 2004, and thus earlier cases could be considered as historical controls.
The patient was reviewed by an oncologist who advised treatment with palliative chemotherapy used for metastatic carcinoma of unknown origin, Epirubicin, Oxaliplatin and Capecitabine.
The patient was treated with 4 courses of cyclophosphamide, epirubicin, and 5-fluorouracil, as well as radiotherapy to the surgical area, followed by weekly treatment with paclitaxel.
Such regimens have largely been superseded by more modern chemotherapy with anthracyclines, with or without taxanes, such as FEC (5-fluorouracil, epirubicin, cyclophosphamide), AC (doxorubicin, cyclophosphamide) and either paclitaxel or docetaxel.
In 334 patients (303 T1) treated with intravesical BCG, epirubicin or adriamycin, the risk of recurrence was significantly higher with intravesical chemotherapy than with BCG.
This class of agents includes doxorubicin, daunorubicin, and epirubicin, which are often used as adjuvant therapy in breast cancer.
Initially, the Fierles alleged that Nurse Mitchell failed to use due care in the administration of the chemotherapy and that negligence caused her to be burned with epirubicin.
The pre-planned three-year interim analysis of a randomised, prospective trial (known as FinXX) compared adjuvant capecitabine in combination with docetaxel and cyclophosphamide plus epirubicin for the treatment of early breast cancer with the standard, non-capecitabine regimen (docetaxel, epirubicin, cyclophosphamide and fluorouracil).
All the women received either a regimen known as "CEF," which contained, in addition to the standard drugs cyclophosphamide and 5-FU, epirubicin (an anthracycline); or an older regimen, "CMF," which contained, in addition to cyclophosphamide and 5-FU, the non-anthracycline methotrexate.
The Gruppo Oncologico Italiano di Ricerca Clinica (GOIRC) study compared D1/D2 surgery alone against surgery followed by four cycles of PELF [cisplatin, epirubicin, leucovorin (LV) and 5-FU] in 258 patients with adenocarcinoma of the stomach at stages Ib, II, IIIa and b, or IV (T4N2M0).
Finally, gastric cancer patients received CDDP, epirubicin, 5-FU and FA or weekly 5-FU plus FA.