Perhaps more problematic than Tisseel's potential effects on epileptiform
activity, edema, or apoptotic changes in the CNS is its potential to induce antibody formation against thrombin of either bovine or human origin.
Furthermore, there is a rare neurological syndrome known as Landau-Kleffner Syndrome (Acquired Epileptic Aphasia) that is associated with regression of language (usually after age 36 months) and an epileptiform
EEG with or without clinical seizures and thus is often confused with autistic regression.
Indeed, studies using animal models have not only served to substantiate clinical findings, but have provided additional insight into subcortical epileptiform
activity that may underlie and precede the convulsions associated with alcohol withdrawal.
Pos = positive; Neg = negative; ND = not done; PLEDS = periodic lateralised epileptiform
discharges; INI = intranuclear and cytoplasmic inclusion bodies.
Analysis showed that unilateral interictal epileptiform
discharges [IEDs], cortical dysgenesis, and younger age at implantation were independent predictors of seizure freedom in the long-term follow-up," they wrote (Seizure 2010;19:264-8).
After 60 days of numerous weaning attempts with return of epileptiform
activity on electroencephalography, the pentobarbital was successfully weaned and discontinued with no significant seizures.
The pearls focus on avoiding pitfalls and complications and cover the basic principles of electricity, acquisition, vocabulary, the normal waking EEG and that of sleep, neonatal polygraphy, focal sharp transients and localization-related epilepsy, generalized discharges and generalized epilepsy, ictal discharges and epileptic seizures, focal lesions, diffuse encephalopathy, periodic epileptiform
discharges, and status epilepticus.
Physiology and pharmacology of epileptiform
activity induced by 4-aminopyridine in rat hippocampal slices.
Biton, entitled "Effects of Lamotrigine in Primary Generalized Tonic-Clonic Seizures (PGTCS): A Randomized, Placebo-Controlled Study, patients naive to LAMICTAL, 2 years of age or older with inadequately controlled PGTC seizures, taking a stable regimen of 1 or 2 AEDs and an electroencephalogram (EEG) with evidence of generalized epileptiform
discharges or no evidence of interictal expression of partial seizures, were enrolled in a randomized, double-blind, placebo-controlled, parallel-group trial.
With respect to magnetic fields, researchers are proposing that perhaps some aspect of these fields have "experience-inducing properties"--even more so if observers have shown a degree of increased neuronal hypersensitivity and susceptibility to these fields (Cook & Persinger, 2001; Makarec & Persinger, 1987; Persinger, 1983, 1984, 1988, 1993a, 1993b; Persinger & Makarec, 1993; Persinger & Koren, 2001; Persinger & Roll, 1985; see also Fuller, Dobson, Wieser, & Moser, 1995, for an example of induced epileptiform
Autism with regression and CDD have both been associated with seizures or epileptiform
sleep-deprived EEG (with adequate sampling of slow wave sleep).
A computerized analysis of electroencephalographic brain mapping showed an irritative epileptiform
focus in the left temporal subcortical area.