epigenome


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epigenome

(e-pij'ĕ-nōm),
Nuclear DNA that is not transcribed to mRNA, making up 90% of the human genome.
[epi- + genome]

epigenome

(ĕp′ĭ-jē′nōm)
n.
The set of heritable chemical changes to an organism's genome, such as DNA methylation or histone modification, that modify gene expression but do not change the DNA sequence itself.

ep′i·ge·no′mic (-jə-nō′mĭk) adj.
References in periodicals archive ?
There is no widely accepted ethical argument with regard to intergenerational equity and the human epigenome.
Noncoding RNA (ncRNA) is perhaps the least understood part of the epigenome.
Alcohol is fast emerging as one of the chief agents to alter the epigenome of cells and tissues throughout the organism.
Persuasive evidence from studies of adult alcoholics and animal models of alcoholism points to multiple connections between alcohol and the epigenome.
The generation of disease-specific epigenome maps will provide complementary and crucial information to the already well-established genome map," he said.
In terms of persistence across generations, the genome has been characterized as "ink" and the epigenome as "pencil":
A group of molecules that sit atop our DNA, the epigenome (which means Aoabove the genomeAo) tells genes when to turn on and off.
The USC Epigenome Center will work with Johns Hopkins University to collect the data from cancer patients over the next five years.
In the last 20 years, however, we have acquired "new microscopes": technologies that examine not the morphology of the tissue but other characteristics such as the genome (point mutations, copy number variation), the epigenome (methylome), the transcriptome, the proteome, the glycome, or the metabolome.
Recent advances in microarrays, nucleic acid mass spectrometry, mass sequencing, and computational biology have made it possible to decode the different levels of the human epigenome from individual patient samples," he said.
The epigenome switches genes on or off in response to signals in its environment.
To identified systemic factors with anti-cardiomyopathic effects by systematic proteomic screenings after parabiosis and epigenome of the DCM hearts.