epigenetic landscape


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epigenetic landscape

a concept related to the developmental PATHWAYS along which a cell passes during differentiation. see CANALIZATION.
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The Dynamic Epigenetic Landscape of the Retina During Development, Reprogramming, and Tumorigenesis.
Their topics include the multifaceted role of YY1 in establishing the cellular epigenetic landscape, identifying mammalian proteins involved in epigenetics, the diverse roles of long non-coding RNA in regulatory processes, the long and short of facioscapulohumeral muscular dystrophy, the environment and the epigenetic transgenerational inheritance of disease, and metabolic inputs into epigenetics.
Regulatory RNAs are known to have roles in controlling the epigenetic landscape of the genome.
The 17 chapters consider relational developmental systems theory and its methodology, its use in positive youth development, and how developmental systems science extends the conceptual and methodological boundaries of developmental science; epigenetic development and evolution, discussing how development directs evolution, and dynamical systems, the epigenetic landscape, and punctuated equilibria; and the connections between neural networks and development, including the nonlinear epigenetic variance in developmental processes and the self-organization metaphor.
Specific DNA methylation patterns differ among tissues and cell types, and these differences contribute to establishing the cells' epigenetic landscape and transcriptional programs and defining cellular identity (Bernstein et al.
Within Fundamentals of Generative Medicine, the reader learns how natural medicines and dietary lectins can shape the genetic and epigenetic landscape.
The Epigenetic Landscape in Embryonic Stem Cells & during Differentiation
Second, are there characteristic histone markers of cancer at specific gene sequences, or will a more global epigenetic landscape of histone and DNA alterations be the most help in cancer diagnosis and prognosis?
Specific objectives are i) to determine how selection affects the miRNA transcriptome and the epigenetic landscape during domestication, ii) to perform a functional characterization of miRNA variants and epigenetic alleles associated with growth, and iii) to validate them as potential epigenetic markers for future selective breeding programmes.
But it was Conrad Waddington who "formulated the concept of the epigenetic landscape, published in its mature form in 1957, to represent the way that developmental decisions are made" (Slack, 2002).
Understanding this so-called epigenetic landscape is therefore vital for all biological mechanisms.
My aim is to understand the relationship between epithelial regeneration and the epigenetic landscape as well as to find the connection between the disarrangements of this system and the onset of IBD.