epigenetics

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Related to epigene: Epigenetics

epigenetics

(ĕp′ĭ-jə-nĕt′ĭks)
n. (used with a sing. verb)
The study of heritable changes in gene expression that are caused by factors such as DNA methylation rather than by a change in the sequence of base pairs in DNA itself.

epigenetics

(ĕp″ĭ-jĕ-nĕt′ĭks)
Changes in the way genes are expressed that occur without changes in the sequence of nucleic acids. In mammals the most common form of epigenetic change results from methylation (the addition of methyl [-CH3] moieties) to the promoter regions of genes. Although epigenetic changes do not alter the sequence of nucleotides, they are inheritable.
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Based on results to date in model systems, we believe that an EpiGene vaccine has the potential to induce CTL responses that are more potent and target more epitopes than vaccines using whole proteins or genes.
Working together with Valentis, we have developed pre-clinical data demonstrating that one of the PINC(TM) formulations is very effective at delivering our EpiGene vaccines.
59b-c hatten sich Phaidon, Apollodoros, Kritoboulos,und sein Vater Kriton, Hermogenes, Epigenes, Aischines, Antisthenes, Ktesippos, M enexenos, Simmias, Kebes, Phaidondes, Eukleides und Terpsion im Gefangnis um den auf seine Hinrichtung wartenden und den Sterbenden versammelt.
Among the local people there was Apollodorus, whom I mentioned, Critobulus and his father, also Hermogenes, Epigenes, Aeschines and Antisthenes.
For example, there appears to be evidence of prions that are associated with disease (see Zaitsev article in November-December 2009 ABT) and epigenes that appear to surround our DNA (see Stein article in April 2012 ABT).