Merkel cell carcinoma: a case series with histopathologic examination.
Primary Cutaneous CD8-Positive Aggressive Epidermotropic
Cytotoxic T-Cell Lymphoma: [CD3.
Cutaneous T-cell lymphoma (CTCL) is a lymphoproliferative disorder of epidermotropic
, neoplastic T-cells with a wide range of clinical manifestations: mycosis fungoides, Sezary syndrome, pleomorphic small/intermediate-cell CTCL and large-cell CTCL.
Initially, the cells are epidermotropic
(migrate to skin); however, with time the malignant T cells lose their affinity for skin and may disseminate internally (6).
Langerhans cells interact with neighboring keratinocytes, which secrete a number of cytokines and epidermotropic
T-cells to form the skin's immune system.
Primary cutaneous lymphomas (PCLs), including primary CTCLs and CBCLs encompass a spectrum of diseases defined by a malignant clonal proliferation of epidermotropic
The neoplastic cells were directly contiguous with the surface epidermis but did not exhibit epidermotropic
migration (Fig 1, a).
lymphoproliferative disorders Primary cutaneous anaplastic large cell lymphoma Lymphomatoid papulosis Subcutaneous panniculitis-like T-cell lymphoma Extranodal NK/T-cell lymphoma, nasal type Primary cutaneous peripheral T-cell lymphoma, unspecified Primary cutaneous aggressive epidermotropic