EFNB2

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EFNB2

A gene on chromosome 13q33 that encodes ephrin-B2, a cell surface GPI-bound ligand for the Eph family of tyrosine kinase receptors, which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. EFNB2 binds to EPHA3, EPHA4, and EPHB4 receptors; with EPHB4 it plays a central role in heart morphogenesis and angiogenesis by regulating cell adhesion and migration. EPHB4-mediated forward signalling controls cellular repulsion and segregation from EFNB2-expressing cells. It may play a role in constraining the orientation of longitudinally projecting axons.
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In this membrane the research team embedded bait, the protein Ephrin-B2, a known target of henipaviruses.
Both research teams found that the virus infects cells by attaching to the Ephrin-B2 protein, a cell receptor found in the brain and in the lining of blood vessels.
For EphA7, EphB2, EphB4, EphB6, ephrin-B1, ephrin-B2, and ephrin-B3, immunohistochemistry was established to visualize some conclusive patterns of tissue-specific expression.
Immunohistochemistry was performed for EphA7, EphB2, EphB4, EphB6, ephrin-B1, ephrin-B2, and ephrinB3.
The high ephrin-B2 expression of the lung tissue was localized, particularly in the bronchial epithelium (Fig.
Although initially characterized in the nervous system, (9) recent knock-out studies have suggested that ephrin-B2 and its EphB4 receptor play key roles in vascular development.
Overexpression of ephrin-B2 and EphB4 has been observed in malignant colonic epithelium.
Symmetrical mutant phenotypes of the receptor EphB4 and its specific trans-membrane ligand ephrin-B2 in cardiovascular development.