EFNA5

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EFNA5

A gene on chromosome 5q21 that encodes ephrin-A5, a cell surface GPI-bound ligand for the Eph family of tyrosine kinase receptors, which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. EFNA5 activates the EPHA3 receptor to regulate cell–cell adhesion and cytoskeletal organisation. With the receptor EPHA2, EFNA5 may regulate lens fibre shape and interactions, and may be key for maintaining lens transparency. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. EFNA5 is the cognate/functional ligand for EPHA7; together they regulate brain development, modulating cell–cell adhesion and repulsion. It interacts with and activates EPHA8.
References in periodicals archive ?
In a mouse model, the UCLA researchers showed that blocking this molecule - called ephrin-A5 - induces axonal sprouting, that is, the growth of new connections between the brain's neurons, or cells, and as a result promotes functional recovery.
Furthermore, investigation of the pooled RNA of eight glioblastoma biopsies revealed six candidates, which were more than fivefold differentially expressed compared with healthy brain tissue: EphA2, ephrin-A4, and EphB4 were up-regulated, whereas EphA1, EphA8, and ephrin-A5 were down-regulated (Fig.
Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by Crkll and Rho-mediated signalling.