EFNA3

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EFNA3

A gene on chromosome 1q21-q22 that encodes ephrin-A3, a cell surface GPI-bound ligand for the Eph family of tyrosine kinase receptors, which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. It interacts with and activates EPHA8.
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They learned that in the areas where stem cells were sleeping, astrocytes were producing high levels of two related molecules -- ephrin-A2 and ephrin-A3.
The team also found that astrocytes in the hippocampus produce not only much lower levels of ephrin-A2 and ephrin-A3, but also release a protein named sonic hedgehoc that, when added in culture or injected into the brain, stimulates neural stem cells to divide and become new neurons.
These findings identify a key pathway that controls neural stem cell growth in the adult brain and suggest that it may be possible to reactivate the dormant regenerative potential by adding sonic hedgehoc, or blocking ephrin-A2 or ephrin-A3," says Dr.
Ephrin-A3 and -B3 were preferentially expressed in the brain, whereas ephrin-A2 and -A4 expression was highest in the colon.
Ephrin-A3 mRNA expression was up-regulated 26-fold in squamous cell lung carcinoma.