The characteristic chemokine receptor on Th2 cells is CCR3, the eotaxin
IL-4 and IL-13 are mediators in the recruitment of eosinophils from blood to tissue, as their presence causes the secretion of chemo-attractant and pro-inflammatory cytokines including eotaxin
proteins (chemokines) and leukotriene [B.
Caption: Supplemental Material, Figure S2: Bronchoalveolar lavage (BAL) IL-6 (A), KC (B), and eotaxin
(C) in WT, TNFR[2.
3,4) In affected patients, eosinophils and other inflammatory cells are released from the bone marrow under the influence of several Th2 cytokines, including interleukin 3 (IL-3), IL-4, IL-5, IL-13, IL-17, and eotaxin
They isolated the chemical eotaxin
and discovered that injecting it into younger mice had the opposite effect, causing fewer brain cells to be produced.
2007) Effect of exercise training on plasma visfatin and eotaxin
Yine olgularda bul sivisinda yuksek duzeylerde IL-5, eotaxin
ve eozinofil katyonik proteini saptanmistir (54-55).
Inflammatory cytokines modulate eotaxin
release by human lung fibroblast cell line.
1992) or inducing the production of the eosinophil chemotactic factor eotaxin
(Rothenberg et al.
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin
While the triggering factor is unknown, eosinophil accumulation in the lungs is now believed to be secondary to the actions of eosinophil-specific chemoattractants, including eotaxin
and regulated upon activation, normal T-cell expressed and secreted (RANTES), and IL-5 released from Th2 lymphocytes in the lungs.
Expression of a functional eotaxin
(CC chemokine ligand 11) receptor CCR3 by human dendritic cells," Journal of Immunology 169(6): 2925-2936.