eotaxin

eotaxin

(ē'ō-tak-sin),
A chemokine with chemoattractant properties for eosinophils, but not for leukocytes.
[eosinophil + G. taxis, orderly arrangement, + -in]

CCL11

A gene on chromosome 17q21.1-q21.2 that encodes eotaxin-1, a CC-type cytokine, which is characterised by two adjacent cysteines and, as with all cytokines, is involved in immunoregulatory and inflammatory processes. Eotaxin-1/CCL11 binds CCR3, is chemotactic for eosinophils—but not mononuclear cells or neutrophils—and is involved in eosinophilic type inflammatory responses (e.g., atopic dermatitis, allergic rhinitis, asthma and parasitic infections).

eotaxin

(e-o-toks'in) [Gr. eos, dawn (rose-colored) + (chemo)taxin]
A chemokine that specifically attracts eosinophils to particular tissues (e.g., to bronchial tissues in asthma or to the skin in contact dermatitis). Tumor necrosis factor alpha stimulates its release. See: chemotaxis; cytokine
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References in periodicals archive ?
The characteristic chemokine receptor on Th2 cells is CCR3, the eotaxin receptor.
IL-4 and IL-13 are mediators in the recruitment of eosinophils from blood to tissue, as their presence causes the secretion of chemo-attractant and pro-inflammatory cytokines including eotaxin proteins (chemokines) and leukotriene [B.
Caption: Supplemental Material, Figure S2: Bronchoalveolar lavage (BAL) IL-6 (A), KC (B), and eotaxin (C) in WT, TNFR[2.
3,4) In affected patients, eosinophils and other inflammatory cells are released from the bone marrow under the influence of several Th2 cytokines, including interleukin 3 (IL-3), IL-4, IL-5, IL-13, IL-17, and eotaxin.
They isolated the chemical eotaxin and discovered that injecting it into younger mice had the opposite effect, causing fewer brain cells to be produced.
Yine olgularda bul sivisinda yuksek duzeylerde IL-5, eotaxin ve eozinofil katyonik proteini saptanmistir (54-55).
Inflammatory cytokines modulate eotaxin release by human lung fibroblast cell line.
1992) or inducing the production of the eosinophil chemotactic factor eotaxin (Rothenberg et al.
Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production.
While the triggering factor is unknown, eosinophil accumulation in the lungs is now believed to be secondary to the actions of eosinophil-specific chemoattractants, including eotaxin and regulated upon activation, normal T-cell expressed and secreted (RANTES), and IL-5 released from Th2 lymphocytes in the lungs.
Expression of a functional eotaxin (CC chemokine ligand 11) receptor CCR3 by human dendritic cells," Journal of Immunology 169(6): 2925-2936.