granulomatosis

(redirected from eosinophilic granulomatosis)
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Related to eosinophilic granulomatosis: Langerhans cell granulomatosis

granulomatosis

 [gran″u-lo″mah-to´sis]
any condition involving the formation of multiple granulomas.
allergic granulomatosis churg-strauss syndrome.
eosinophilic granulomatosis Langerhans cell histiocytosis.
Langerhans cell granulomatosis Langerhans cell histiocytosis.
lymphomatoid granulomatosis a multisystem disease involving predominantly the lungs, skin, central nervous system, and kidneys, caused by invasion and destruction of vessels by atypical lymphoreticular cells. Many affected patients develop frank lymphoma. It usually affects males, and the most frequent presenting symptoms are cough, shortness of breath, and chest pain. Extrapulmonary manifestations are common, with skin lesions being present in many cases.
granulomatosis sidero´tica a condition in which brownish nodules are seen in the enlarged spleen.
Wegener's granulomatosis a multisystem disease chiefly affecting males, characterized by necrotizing granulomatous vasculitis involving the upper and lower respiratory tracts, glomerulonephritis, and variable degrees of systemic, small vessel vasculitis, which is generally considered to represent an aberrant hypersensitivity reaction to an unknown antigen.

gran·u·lo·ma·to·sis

(gran'yū-lō-mă-tō'sis),
Any condition characterized by multiple granulomas.

granulomatosis

/gran·u·lo·ma·to·sis/ (gran″u-lo″mah-to´sis) the formation of multiple granulomas.
eosinophilic granulomatosis  Langerhans cell histiocytosis.
Langerhans cell granulomatosis  see under histiocytosis.
granulomatosis sidero´tica  a condition in which brownish nodules are seen in the enlarged spleen.
Wegener's granulomatosis  a progressive disease, with granulomatous lesions of the respiratory tract, focal necrotizing arteriolitis and, finally, widespread inflammation of all organs of the body.

granulomatosis

[gran′yoo͡lōmətō′sis]
Etymology: L, granulum + Gk, oma, tumor, osis, condition
a condition or disease characterized by the development of granulomas, such as berylliosis, pulmonary Wegener's granulomatosis, or Wegener's granulomatosis.

granulomatosis

Any condition characterized by multiple nodules or granulomas. See Bronchocentric granulomatosis, Lymphomatoid granulomatosis, Necrotizing sarcoid granulomatosis, Wegener's granulomatosis.

gran·u·lo·ma·to·sis

(gran'yū-lō'mă-tō'sis)
Any condition characterized by the presence of granulomas.

granulomatosis

Any disease featuring multiple granulomas.

granulomatosis

the formation of multiple granulomas.

lymphomatoid granulomatosis
a lymphohistiocytic proliferative disorder in dogs, usually involving viscera but occasionally including skin lesions.
Wegener's granulomatosis
a mononuclear granulomatous disease characterized by granulomatous inflammation and necrotizing vasculitis.
References in periodicals archive ?
An uncommon presentation of eosinophilic granulomatosis with polyangiitis: a case report.
Eosinophilic granulomatosis with polyangiitis (Churg-Strauss) : clinical characteristics and long-term followup of the 383 patients enrolled in the French Vasculitis Study Group cohort.
Among patients with granulomatosis with polyangiitis (GPA) or eosinophilic granulomatosis with polyangiitis (EGPA), the presence of skin lesions approximately doubled the likelihood of renal, pulmonary, neurologic, or other severe systemic manifestations of ANCA-associated vasculitis (hazard ratios, 2.
This study demonstrates that skin lesions are quite common and varied in granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis," the investigators concluded.
Anti-neutrophil cytoplasmic antibodies are a group of autoantibodies associated with diseases such as granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis.
The autoimmune/idiopathic disorders most commonly associated with eosinophilia are eosinophilic granulomatosis with polyangiitis (EGPA, also known as Churg-Strauss syndrome), Kimura disease, immunoglobulin (Ig)G4-related disease, diffuse fasciitis with eosinophilia, and eosinophilic myositis.
Differential Diagnosis of Eosinophilia Common reactions: medications, parasites, asthma/allergy Adrenal insufficiency due to critical illness Multiorgan autoimmune/idiopathic diseases, especially EGPA/Churg-Strauss syndrome Single-organ eosinophilic diseases, especially lung, GI, skin Myeloid neoplasms with eosinophilia Secondary eosinophilia due to lymphoid or epithelial neoplasms Congenital syndromes: hyper-IgE, Omenn syndrome, familial eosinophilia Abbreviations: EGPA, eosinophilic granulomatosis with polyangiitis; GI, gastrointestinal disease; IgE, immunoglobulin E.
Mepolizumab is in development for COPD, severe eosinophilic asthma and Eosinophilic Granulomatosis with Polyangiitis (EGPA).
Of these, eosinophilic granulomatosis with polyangiitis, formerly known as Churg-Strauss syndrome, is associated with severe eosinophilia.

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