eosinophilic granuloma


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.
Related to eosinophilic granuloma: Langerhans cell histiocytosis

granuloma

 [gran″u-lo´mah] (pl. granulomas, granulo´mata)
an imprecise term applied to (1) any small nodular, delimited aggregation of mononuclear inflammatory cells, or (2) a similar collection of modified macrophages resembling epithelial cells, usually surrounded by a rim of lymphocytes, often with multinucleated giant cells. Some granulomas contain eosinophils and plasma cells, and fibrosis is commonly seen around the lesion. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents.
apical granuloma modified granulation tissue containing elements of chronic inflammation located adjacent to the root apex of a tooth with infected necrotic pulp.
actinic granuloma an annular lesion seen on skin chronically exposed to the sun, with a raised border and a center that appears normal but is actually elastotic.
benign granuloma of thyroid chronic inflammation of the thyroid gland, converting it into a bulky tumor that later becomes extremely hard.
coccidioidal granuloma the secondary stage of coccidioidomycosis.
dental granuloma one usually surrounded by a fibrous sac continuous with the periodontal ligament and attached to the root apex of a tooth.
eosinophilic granuloma
2. a disorder similar to eosinophilic gastroenteritis, characterized by localized nodular or pedunculated lesions of the submucosa and muscle walls, especially of the pyloric area of the stomach, caused by infiltration of eosinophils, but without peripheral eosinophilia and allergic symptoms.
granuloma fissura´tum a firm, whitish, fissured, fibrotic granuloma of the gum and buccal mucosa, occurring on an edentulous alveolar ridge and between the ridge and the cheek.
foreign-body granuloma a localized histiocytic reaction to a foreign body in the tissue.
giant cell reparative granuloma, central a lesion of the jaws composed of a spindle cell stroma punctuated by multinucleate giant cells, considered by most to be a central lesion of the bone of the jaws, presenting an inflammatory reaction to injury or hemorrhage. Some, however, consider it to be a giant cell tumor occurring in both benign and malignant forms, and others consider it to be a form of osteogenic sarcoma, varying in degree of malignancy.
granuloma inguina´le a granulomatous disease that is associated with uncleanliness and is caused by the microorganism Calymmatobacterium granulomatis (sometimes called a Donovan body). Called also granuloma venereum. Although granuloma inguinale is often considered to be a venereal disease, research does not support the hypothesis that it is transmitted by sexual contact. It is possible that natural resistance to the disease is high, so that only a few of the persons exposed are affected. About 10 days to 3 months may elapse after exposure until appearance of the first symptoms, usually small painless ulcers that bleed easily. Swelling in the groin may then follow. A new ulcer or ulcers may appear as the old one heals, so that granuloma inguinale may eventually cover the reproductive organs, buttocks, and lower abdomen, with extensive sores and a foul odor. As persons who have the disease seem to develop little immunity to it, granuloma inguinale can be present for many years.

Treatment of the disease may be with streptomycin. tetracyclines, or lincomycin. There is no known preventive for granuloma inguinale, although it is rare where sanitary living conditions prevail. The drainage from lesions may be infectious and handwashing and basic cleanliness are required. The Centers for Disease Control and Prevention recommends standard precautions.
lipoid granuloma xanthoma.
lipophagic granuloma a granuloma attended by the loss of subcutaneous fat.
Majocchi's granuloma trichophytic granuloma.
midline granuloma a rare disease of unknown etiology, characterized by granulomatous lesions of the nasal mucosa, sinuses, palate, and pharynx. Massive, progressive, erosive lesions that destroy the involved soft tissue, cartilage, and bone and sometimes extend to the brain are typical. Untreated cases are fatal (lethal midline granuloma).
paracoccidioidal granuloma paracoccidioidomycosis.
peripheral giant cell reparative granuloma giant cell epulis.
pyogenic granuloma a benign, solitary nodule resembling granulation tissue, found anywhere on the body, commonly intraorally, usually at the site of trauma as a response of the tissues to a nonspecific infection.
sarcoid granuloma the granuloma seen with sarcoidosis, consisting of multinucleated giant cells surrounded by macrophages and epithelioid cells derived from macrophages.
swimming pool granuloma a chronic granulomatous bacterial infection caused by contamination of an abrasion sustained in a swimming pool by Mycobacterium marinum, which histologically and clinically resembles tuberculosis. It tends to heal spontaneously within a few months to 2 years.
granuloma telangiecta´ticum a form characterized by numerous dilated blood vessels.
trichophytic granuloma a form of tinea corporis seen mainly on the lower legs, due to infection of hairs by the fungus Trichophyton; characteristics include raised, circumscribed, boggy granulomas that are disseminated or arranged in chains. Lesions are slowly absorbed or undergo necrosis, leaving depressed scars. Called also Majocchi's granuloma.
granuloma tro´picum yaws.
granuloma vene´reum granuloma inguinale.

e·o·sin·o·phil·ic gran·u·lo·ma

a form of Langerhans histiocytosis predominantly involving the bones of young people; may be solitary or multiple; histologically composed of Langerhans cells and eosinophils.

eosinophilic granuloma

n.
A form of Langerhans cell histiocytosis characterized by multifocal erosions of the bones, especially the skull and long bones.

eosinophilic granuloma

1 a simple or multiple growth in the bone or lung characterized by numerous eosinophils and histiocytes. Eosinophilic granulomas occur most frequently in children and adolescents.
2 See anisakiasis.

eosinophilic granuloma

Medtalk A benign clinical form of histiocytosis X, characterized by circumscribed cystic osseous lesions in children and adolescents composed of eosinophils and histiocytes. See Langerhans' cell histiocytosis.

e·o·sin·o·phil·ic gran·u·lo·ma

(ē'ō-sin-ō-fil'ik gran'yū-lō'mă)
A lesion observed more frequently in children and adolescents, occasionally in young adults, which occurs chiefly as a solitary focus in one bone, although multiple involvement is sometimes observed and similar foci may develop in the lung; characterized by numerous Langerhans cells and eosinophils, and occasional foci of necrosis; may be related to Hand-Schüller-Christian disease, possibly representing a benign form.

e·o·sin·o·phil·ic gran·u·lo·ma

(ē'ō-sin-ō-fil'ik gran'yū-lō'mă)
A lesion observed more frequently in children and adolescents, occasionally in young adults, which occurs chiefly as a solitary focus in one bone, although multipleinvolvement is sometimes observed and similar foci may develop in the lung.

eosinophilic granuloma,

eosinophilic

staining readily with eosin; pertaining to eosinophils or to eosinophilia.

cartilaginous eosinophilic streaks
streaks of eosinophilic matrix in cartilage. Some are normal zones of development, others represent areas of matrix degeneration and osteochondrosis.
eosinophilic chemotactic factor
a primary mediator of type I anaphylactic hypersensitivity, it is an acidic peptide (molecular weight 500) released by mast cells, which attracts eosinophils to areas where it is present.
equine eosinophilic chronic dermatitis
acanthosis and hyperkeratosis accompanied by eosinophilic granulomas in pancreas and other epithelial organs.
feline eosinophilic granuloma complex
a collective name given to the lesions of eosinophilic ulcer, eosinophilic plaque (below), and linear granuloma because of similarities in histopathology, clinical course and occasionally simultaneous occurrence in the cat.
eosinophilic granuloma
nodules or plaques that occur on skin or oral mucosa of dogs. Usually not pruritic, but oral lesions can cause some difficulties in eating. The cause is unknown. See also feline eosinophilic granuloma complex (above), equine nodular collagenolytic granuloma.
eosinophilic intestinal granuloma
see angiostrongyluscostaricensis.
eosinophilic lung disease
eosinophilic meningitis
see gnathostomaspinigerum.
eosinophilic meningoencephalitis
see sodium chloride poisoning, angiostrongyluscantonensis.
eosinophilic myocarditis
in cattle may be observed in normal animals at slaughter. Histologically there is a predominant eosinophil invasion of the heart muscle. May be accompanied by similar lesions in skeletal muscles.
eosinophilic plaque
well-defined, raised, ulcerated and extremely pruritic lesions that occur on the skin of cats, usually on the abdomen or hindlegs. There are large numbers of eosinophils present in the dermis and sometimes peripheral blood. See also eosinophilic granuloma (above), feline eosinophilic granuloma complex (above).
eosinophilic pneumonia
eosinophilic ulcer
a well-defined ulceration, usually on the upper lip of cats overlying the canine tooth, which is shallow initially but can become extremely erosive and sometimes neoplastic. Mildly irritating to the cat. Called also indolent ulcer, rodent ulcer. See also feline eosinophilic granuloma complex (above).
Enlarge picture
Bilateral eosinophilic ulcer. By permission from Kummel BA, Color Atlas of Small Animal Dermatology, Mosby, 1989
References in periodicals archive ?
Several lesions that can be polyostotic include multiple hereditary exostoses, enchondromas, fibrous dysplasia and, occasionally, eosinophilic granulomas.
The radiographic appearance of osteoarticular tuberculosis can mimic metastatic tumors or primary osseous lesions such as eosinophilic granuloma, especially if multiple destructive lesions are present.
Patients with eosinophilic granuloma usually present with otorrhea, conductive hearing loss, and symptoms mimicking those of persistent otitis media or mastoiditis.
Given the histopathology and physical examination findings, the child was diagnosed with eosinophilic granuloma.
Eosinophilic granuloma is the most benign of the three conditions.
Eosinophilic granuloma manifests clinically as osteolytic lesions of the skull, long bones, ribs, and/or vertebrae; there is a notable lack of systemic involvement.
Bilateral temporal bone involvement with eosinophilic granuloma.
Breast carcinoma, eosinophilic granuloma of bone and dermatomyositis in a single patient.
Eosinophilic granuloma of the temporal bone: Medical and surgical management in the pediatric patient.
Localized eosinophilic granuloma (Langerhans' cell histiocytosis) of the orbital frontal bone.
Among the possible causes are (1) congenital lesions, such as osteogenesis imperfecta and cholesteatomas; (2) inflammatory lesions and diseases, such as cholesterol granulomas, osteomyelitis, and mastoiditis; (3) fibro-osseous disease, such as fibrous dysplasia and Paget's disease; (4) benign and malignant neoplasms, such as chordomas and nasopharyngeal carcinomas; and (5) infiltrative lesions, such as eosinophilic granulomas and xanthomas.

Full browser ?