major basic protein

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major basic protein

a cytotoxic and proinflammatory mediator found in eosinophil granules.

major basic protein

An 11-kD major cytotoxic and helminthotoxic protein encoded by PRG2 on chromosome 11q12, which forms a characteristic crystalloid and is found in the granules of eosinophils and other myeloid cells. It induces non-cytolytic histamine release from human basophil, and is involved in antiparasitic defence and immune hypersensitivity reactions.

The adjectival “basic” derives from MBP’s isoelectric point of greater than pH 10. MBP is capable of killing parasites, as well as host cells; it causes bronchial epithelial damage and a wheal and flare response when injected subcutaneously, and it has been linked to asthma.
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Localization of pregnancy-associated plasma protein-A and colocalization of pregnancy-associated plasma protein-A messenger ribonucleic acid and eosinophil granule major basic protein messenger ribonucleic acid in placenta.
Deposition of eosinophil granule major basic protein in eosinophilic gastroenteritis and celiac disease.
Regulation and processing of a precursor form of eosinophil granule major basic protein (ProMBP) in differentiating eosinophils.
Acidic precursor revealed in human eosinophil granule major basic protein cDNA.
Elevated serum levels in human pregnancy of a molecule immunochemically similar to eosinophil granule major basic protein.

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