enzyme inhibitor


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enzyme inhibitor

a molecule that prevents an enzyme from catalysing a reaction. Such inhibitors can compete with the normal substrate (see COMPETITIVE INHIBITION or can block the active site, preventing entry of the substrate (see NONCOMPETITIVE INHIBITION). Inhibition may be reversible or irreversible. Enzyme inhibitors often form part of a FEEDBACK MECHANISM to regulate a biochemical pathway.
References in periodicals archive ?
Angiotensin converting enzyme inhibitor induced angio-oedema: a review of the pathophysiology and risk factors.
Angioedema incidence in US veterans initiating angiotensin-converting enzyme inhibitors.
Objective: To compare efficacy of calcium channel blockers (CCBs) with angiotensin converting enzyme inhibitors (ACEIs) in the treatment of elderly men (age more than 55 years) with essential hypertension.
Hsu, Bates, Kuperman & Curhan (2001), in their study, "Blood pressure and angiotensin converting enzyme inhibitor use in hypertensive patients with chronic renal insufficiency," sought to investigate actual clinical management of hypertension in 3,089 ambulatory patients with CKD by using medical record information from a Massachusetts hospital.
Shades of colour can be correlated to the amount of substrate or enzyme inhibitor present.
The covalently bound entity may also serve as an antagonist or agonist of a particular binding protein or as an enzyme inhibitor.
Temsirolimus is an enzyme inhibitor that blocks a specific T-cell function.
The UP-induced activation of ERK1/2 and p38 was attenuated by captopril, an angiotensin-converting enzyme inhibitor.
2% of residents with congestive heart failure were not receiving an angiotensin-converting enzyme inhibitor.
The immobilizing agent has a melting point of at least about 35[degrees]C and the enzyme inhibitor has an IC50 of about 50 mM or less, as measured by a General Fecal Enzyme Method.
NEW ORLEANS -- Angiotensin-converting enzyme inhibitor therapy markedly reduces the rate of shocks for ventricular arrhythmias in patients with an implantable cardioverter defibrillator, Dr.
The enzyme inhibitor can be used as a form of early intervention to delay the onset of life-threatening metabolic disorders.