entry inhibitor


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Related to entry inhibitor: protease inhibitor, Reverse transcriptase inhibitors, Integrase inhibitor

entry inhibitor

Any agent that prevents a pathogen (e.g., human immunodeficiency virus) from binding to cell membranes and infecting cells.
Synonym: attachment inhibitor
See also: inhibitor
References in periodicals archive ?
Because entry inhibitors work outside of the cells, there's no threat of intracellular damage, a danger with some other anti-HIV drugs.
announced today that it has received Notices of Allowance from the United States Patent Office for key patent applications related to the use of Monogram's phenotypic technology for assessing the efficacy of entry inhibitors, a new class of drug that prevents HIV from entering cells.
Entry inhibitors don't attack the HIV virus directly, explained Dr.
They will do this while using drugs that prevent new HIV infections, eg, entry inhibitors and RT inhibitors.
Classes of entry inhibitors include coreceptor inhibitors (these block HIV's interaction with coreceptors such as the chemokines CCR5 and CXCR4) and fusion inhibitors (these prevent the virus from fusing with the cell membrane).
Human Immunodeficiency Virus HIV Protease Inhibitors HIV Non-nucleoside Reverse Transcriptase Inhibitors HIV Nucleoside Reverse Transcriptase Inhibitors HIV Entry Inhibitors HIV Integrase Inhibitors Hepatitis C Virus Protease Inhibitors HCV Polymerase Nucleoside Inhibitors Other HCV Inhibitors Respiratory Syncytial Virus Inhibitors Influenza, Hepatitis B, and Cytomegalovirus Inhibitors
High-throughput screening was used to identify the HIV-blocking molecules, which came to be known as gp 120 targeted entry inhibitors.
RITA: Some people view the entry inhibitors in development as the next great hope in HIV treatments, possibly replacing some classes of antiretroviral agents as first-line treatments: a second-generation HAART, if you will.
The SBIR award will allow ImQuest to better define the putative entry inhibition target, thus allowing the eventual development of an entirely new class of virus entry inhibitors.
The Second Collaborative Research Seminar on HIV and Other Viral Entry Inhibitors, May 3-5, 2002, The Waldorf Astoria, New York, NY The Macrae Group, 230 East 79th St, Suite 8E, NY 10021, 212-988-7732 212-7171222 macraegrp@binternet.
New technologies to assess resistance to entry inhibitors such as T-20 and T-1249 are in development.