It was really stimulation in the gateway to the hippocampus - the entorhinal cortex
- where we got the beneficial effect in terms of memory," Fried said.
23] The earliest neuritic plaques were identified in the hippocampus and entorhinal cortex
of a 23-year-old patient and were prominent in the hippocampus and neocortex in the 3 oldest patients ([is greater than] 44 years) (Figure 3), all of whom also had frequent diffuse plaques.
It enters the limbic system through the entorhinal cortex
Theta waves are fairly low-frequency electrical oscillations that also have been observed at the cellular level in the medial entorhinal cortex
However, such individuals maybe prone to mental declines as the entorhinal cortex
shrinks with age, the scientists theorize.
In fact, this working memory-like persistent activity occurred in the entorhinal cortex
even under anesthesia.
Furthermore, the autistic brain showed a clear zone between two cell layers in the entorhinal cortex
, a characteristic that normally appears during the second trimester of fetal life and disappears by age 15 months.
The entorhinal cortex
is one of the first brain regions to degenerate in Alzheimer's disease, so our results may help to explain why disorientation is one of the first behavioural signs of Alzheimer's," said senior author Elizabeth Buffalo, PhD, associate professor of neurology at Emory University School of Medicine and Yerkes National Primate Research Center.
All participants were given a 16-word list learning task to measure verbal recall, and underwent magnetic resonance imaging, MRI, to measure volumes of regions of the medial temporal lobes, specifically the hippocampus, entorhinal cortex
and parahippocampal cortex.
In terms of effect size, ROIs in the mesial temporal lobe, including the entorhinal cortex
, and, in particular, the hippocampus, stood out as the most important in all three groups of patients, compared with controls.
In particular, Mehta and his team looked at three connected brain regions in mice - the new brain or the neocortex, the old brain or the hippocampus, and the entorhinal cortex
, an intermediate brain that connects the new and the old brains.
42] plaques in the entorhinal cortex
, hippocampus, and amygdala.