enthesitis


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en·the·si·tis

(en-thĕ-sī'tis),
Condition occurring at the insertion of muscles where recurring concentration of muscle stress provokes inflammation with a strong tendency toward fibrosis and calcification.
[G. enthetos, implanted, + -itis, inflammation]

enthesitis

[en′thəsī′tis]
an inflammation of the insertion of a muscle with a strong tendency toward fibrosis and calcification. It is usually only painful when the involved muscle is activated.

en·the·si·tis

(en'thĕ-sī'tis)
Traumatic disease occurring at the insertion of muscles where recurring concentration of stress provokes inflammation with a strong tendency toward fibrosis and calcification.
[G. enthetos, implanted, + -itis, inflammation]

enthesiopathy

; enthesitis acute or chronic inflammation at insertion of tendon or ligament into periosteum and underlying bone, characterized by local pain and/or swelling, and possible spur formation; complication of plantar fasciitis; typical of anykylosing spondylitis and other sero-negative arthropathies (see Table 1)
Table 1: Common features of the range of types of sero-negative inflammatory arthritis
FeatureComment
Leukocyte antigen type90% of patients with sero-negative arthritis test positive for human leukocyte antigen (HLA) B27
Skeletal involvementAxial skeleton/spinal involvement; with back pain (common presenting first symptom)
EnthesopathyInflammation at insertions of ligaments/tendons (posterior calcaneum, plantar calcaneum, base of fifth metatarsal, forefoot)
Soft-tissue swellingsLocalized swelling at Achilles tendon insertion
Bursitis of congenital/adventitious bursae
SynovitisDactylitis/'sausage' toe
Generalized swelling of fore foot
VasculitisNote: Does not tend to affect foot in sero-negative arthritides
RadiographsBone/periosteal fluffy/'whiskery' proliferation
New bone/spur formation at entheses, secondary to inflammation

enthesitis (en·th·siˑ·tis),

n condition characterized by recurring, concentrated stress at points of muscle insertion that leads to inflammation and possible calcification and fibrosis.
References in periodicals archive ?
Presence of dactylitis (assessed by dactylitic digit count) and enthesitis (assessed by a four-point enthesitis index) amongst subjects with these characteristics at baseline
In terms of PsA treatment approaches, an evidence review that he and his associates in GRAPPA published in 2009 found that biologies (anti-tumor necrosis factor inhibitors) as a group were effective in all five domains of the disease: peripheral arthritis, skin and nail disease, axial disease, dactylitis, and enthesitis, while the oral disease-modifying antirheumatic drugs (DMARDs) were effective for peripheral arthritis and skin and nail disease.
Enthesitis-related arthritis was formerly known as spondyloarthropathy or spondyloarthritis and includes patients with varying presence of arthritis and enthesitis as well as ankylosing spondylitis.
The enthesitis scores and changes from baseline in PGA, ESR and CRP values at three months of TNF blocker treatment are shown in Table 2.
2] Similarly, PsA (including peripheral arthritis, axial disease, enthesitis and dactylitis) has shown a rapid and significant response to TNFi with inhibition of radiographic disease progression.
The prediction model incorporated patient age, enthesitis score, CRP level, Bath AS Functional Index (BASFI) score, and HLA-B27 genotype.
The effects of MTX on PsA-specific manifestations, such as enthesitis, dactylitis, and spondylitis, have not been studied.
They may also have an enthesitis which may manifest as Achilles tendinitis,plantar fasciitis or tendinitis, plantar fasciities or tenderness at other enthseseal Axial involvement with inflammatory back pain and sacroiliitis is uncommon.
Therefore, we assessed whether bacterial peptidoglycan (PG), LPS, flagellin, CpG DNA), and viral (poly I:C, and imiquimod) products have similar stimulatory effect like cytokines IL-[beta] and TNF-[alpha] on synovial fibroblast from patients with enthesitis related arthritis (ERA) subset of JIA to produce MMP3 and MMP1 and its inhibitor TIMP1.
Claire, of Huntington Close, Kingston Park, Newcastle, said: "Five years ago I was diagnosed with enthesitis ( a form of arthritis which affects my back and my hips.
About Ankylosing Spondylitis Ankylosing spondylitis (AS) is a chronic, immune-mediated disease that causes enthesitis, or inflammation where ligaments and muscles attach to bones, most commonly those within the spine.
2) Beside subjective scales such as Mander and Maastricht Ankylosing Spondylitis Enthesitis Indices, (3) a lot of objective laboratory markers like erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), immunoglobulin A, G and M, complements C3 and C4, interferon-gamma, interleukin-4, alpha-1-antitrypsin, and serum amyloid A were suggested to be used in evaluating disease activity in AS.