enterohepatic recirculation

enterohepatic recirculation

Biliary recycling Therapeutics The cycling of drugs and metabolites after excretion in the biliary system, which are reabsorbed in the intestine. Cf Absorption.
References in periodicals archive ?
The partner to the gut is the liver and there is an amazing connection called the enterohepatic recirculation, which helps the body process chemicals in the liver and prepare it for non-toxic excretion in the gut.
Deconjugation and reabsorption of some bilirubin for enterohepatic recirculation.
As a result of the prolonged absorption time and enterohepatic recirculation of DDS, methaemoglobinaemia may persist for several days following DDS ingestion.
This would preclude enterohepatic recirculation in humans, in contrast to rats, in which intestinal [beta]-glucuronidases could break down excreted conjugate and liberate BPA for systemic reabsorption.
Most important is the fact that ethinyloestradiol undergoes eventual enterohepatic recirculation.
The pharmacokinetic profile of 8-PN was characterized by rapid and probably complete enteral absorption, high metabolic stability, pronounced enterohepatic recirculation and tight dose linearity.
A high fiber diet reduces circulating estrogens by reducing enterohepatic recirculation of estrogen.
15) In comparison, concomitant cholestyramine use will interfere with the enterohepatic recirculation of MPAG thereby facilitating a 40% drop in plasma MPA metabolite levels in kidney transplant recipients.
The structure of soy isoflavones is similar to the natural synthetic female sex hormone 17 [beta]-estradiol and ethinyl estradiol which also undergoes enterohepatic recirculation (22).
As a result, the interaction between MMF and Tc or CsA is probably not attributable to one mechanism but is related to a possible inhibitory effect of Tc on MPA metabolism and to an inhibition of the enterohepatic recirculation of MPA by CsA.
Penicillins appear to interact with oral contraceptives unpredictably, possibly by reducing the bacterial hydrolysis of estrogens in the gastrointestinal tract and thereby reducing enterohepatic recirculation.
However, a number of basic structural hypotheses such as enterohepatic recirculation, plasma binding, and flow--or diffusion-limited treatment of tissue distribution require additional evaluation and analysis.