Founded in 2015, after six years of work as part of GlaxoSmithKline's Enteroendocrine
Discovery Performance Unit, Phoundry Pharmaceuticals created a portfolio of optimized peptides in various therapeutic categories, most notably diabetes and obesity, which attracted the acquisition by Intarcia.
Indeed, women with ICP are more susceptible to developing GDM and have significant biochemical and endocrine changes such as increased basal endogenous glucose production, decreased insulin sensitivity, and reduced GLP1 secretion from enteroendocrine
L-cells that result in altered carbohydrate metabolism while they are cholestatic.
Hormones secreted by the enteroendocrine
cells of the small intestine in response to the presence of fat in the proximal duodenum stimulate contractions of the smooth muscle of the gallbladder.
Craig Smith, a Senior Lecturer in Molecular Cell Physiology, said that their research centred on enteroendocrine
cells that 'taste' what we eat and in response release a cocktail of hormones that communicate with the pancreas, to control insulin release to the brain, to convey the sense of being full and to optimize and maximize digestion and absorption of nutrients.
The issue here is that the intestinal tract and inflammatory bowel and Crohn's disease is found to have excessive amounts of serotonin in the enteroendocrine
In addition, the gut specific sensory, sympathetic nerves, and enteroendocrine
cells can trigger the release of CRF (Karalis et al.
Increased rectal mucosal enteroendocrine
cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome.
Ghrelin is produced by the P/D1 cells, a cell-type distinct from the other enteroendocrine
Both the enteroendocrine
cell and Paneth's cell are deriving from the undifferentiated cell which is considered as stem cell of enteric epithelium.
Ghrelin is a 28 amino acid gastric hormone that is released from the enteroendocrine
cells of the stomach and large intestine that stimulates appetite (Cummings and Overduin, 2007; Cummings et al.
GIP and GLP-1 are released from intestinal enteroendocrine
cells in response to a glucose load and account for over 50% of insulin secreted in response to a meal.
The SCFAs also affect the serotonin- and motilin-containing enteroendocrine
cells in the colon and the ileum (44).