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enfuvirtide |
Also found in: Wikipedia | 0.07 sec. |
enfuvirtide Fuzeon Pharmacologic class: Human immunodeficiency-1 (HIV-1) fusion inhibitor Therapeutic class: Antiretroviral Pregnancy risk category B ActionInterferes with entry of HIV-1 into cells by inhibiting fusion of viral and cellular membranes AvailabilityPowder for injection: 90 mg/1-ml vial ⊘Indications and dosages ➣ HIV-1 infection Adults: 90 mg subcutaneously b.i.d. in upper arm, anterior thigh, or abdomen Children ages 6 to 16: 2 mg/kg subcutaneously b.i.d. in upper arm, anterior thigh, or abdomen. Maximum dosage is 90 mg b.i.d. Contraindications• Hypersensitivity to drug or its components PrecautionsUse cautiously in: Administration• Rotate injection sites.
Adverse reactionsCNS: fatigue, asthenia, insomnia, depression, anxiety, peripheral neuropathy EENT: conjunctivitis, sinusitis GI: nausea, diarrhea, upper abdominal pain, dry mouth, anorexia, pancreatitis Hematologic: lymphadenopathy Musculoskeletal: limb pain, myalgia Respiratory: cough, pneumonia Skin: folliculitis Other: taste disturbance, decreased appetite, weight loss, herpes simplex infection, injection site reactions (erythema, induration, nodules, cysts, mild to moderate pain, infection), flulike illness, hypersensitivity reactions InteractionsDrug-diagnostic tests. Alanine aminotransferase, amylase, aspartate aminotransferase, creatine kinase, eosinophils, gamma-glutamyltransferase, lipase, triglycerides: increased levels Hemoglobin: decreased level Patient monitoring• Inspect injection sites frequently for adverse reactions. Patient teaching• Teach patient (or caregiver) how to reconstitute and self-administer drug, as appropriate. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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? Mentioned in | ? References in periodicals archive | |
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For experienced patients, "This section has been updated to redefine the goal of antiretroviral therapy in the management of treatment-experienced patients with virologic failure and to review the role of more potent ritonavir-boosted protease inhibitors such as tipranavir with or without enfuvirtide in these patients. Major additions to the drug armamentarium came in 1998 with efavirenz (Sustiva), in 2000 with lopinavir/ritonavir (Kaletra), in 2001 with tenofovir DF (Viread), and--arguably--in 2003 with enfuvirtide (Fuzeon, T-20), the first fusion inhibitor, and with atazanavir (Reyataz). I have concerns about patients whose virus is not purely CCR5-tropic, even though agents like TNX355, enfuvirtide (Fuzeon), and CCR5 antagonists may all be combinable. |
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