component of Gram-negative bacteria, LPS, is found on the outer bacterial membrane and is responsible for eliciting strong immune responses, associated with infection, by binding to and activating TLR4.
Neuropeptide Y restores appetite and alters concentrations of GH after central administration to endotoxic
The research team investigated the role of H2S in endotoxic
shock, which causes a fatal loss of blood pressure and extensive tissue inflammation.
shock after gamete intrafallopian transfer.
Preclinical studies have repeatedly demonstrated semapimod's efficacy in animal models of inflammatory and proliferative diseases, including endotoxic
shock and toxicity, pancreatitis, ischemia and stroke, necrotizing enterocolitis, and neointimal formation.
Mice deficient for the 55 kDa tumor necrosis factor receptor are resistant to endotoxic
shock, yet succumb to L monocytogenes infection.
Animal experiments have shown that changes in AKBR reflect the energy charge of the liver and the liver mitochondrial function during endotoxic
shock, jaundice, and after liver transplantation [39-41].
Striking anti-inflammatory effects were demonstrated with IRHs in in vivo models of pleurisy (a model of lung inflammation), EAE (experimental autoimmune encephalomyelitis, a model of multiple sclerosis) and LPS challenge (lipopolysaccharide, a lethal model of endotoxic
Dexamethasone inhibits lipopolysaccharide-induced hydrogen sulphide biosynthesis in intact cells and in an animal model of endotoxic
Myocardial lactate deprivation is associated with decreased cardiovascular performance, decreased myocardial energetics, and early death in endotoxic
Changes in serum profile, cholesterol and blood glucose during endotoxic
shock in buffalo calves supplemented with Vitamin E and selenium.
Nitric oxide production during endotoxic
shock in carbon tetrachloride-treated rats.