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endotoxic |
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Mice deficient for the 55 kDa tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L monocytogenes infection. 89 93 Other potential therapeutic roles of NO include the treatment of endotoxic shock, adult respiratory distress syndrome, and hypertension in various disease states such as atherosclerosis and chronic renal failure. Striking anti-inflammatory effects were demonstrated with IRHs in in vivo models of pleurisy (a model of lung inflammation), EAE (experimental autoimmune encephalomyelitis, a model of multiple sclerosis) and LPS challenge (lipopolysaccharide, a lethal model of endotoxic shock). |
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