endothelium-derived

(redirected from endothelium-derived vasoactive substances)

endothelium-derived

derived from endothelium.

endothelium-derived vasoactive substances
substances produced by or released from endothelial cells which regulate vascular smooth muscle or other regulatory mechanism; include prostacyclin and other prostanoids, angiotensin, and relaxing or constricting factors.
endothelium-derived constricting factor
vasoconstrictive peptides isolated from vascular endothelial cells which are actively vasoconstrictive; endothelin (ET) is the most active of them.
endothelium-derived relaxing factor
several are known; nitrous oxide is one of the chief mediators, probably derived from l-arginine.
References in periodicals archive ?
The balance between these opposing endothelium-derived vasoactive substances under nonpathological and pathological conditions ultimately determines the contractile and perhaps the mitogenic state of the underlying vascular smooth muscle.

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