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endothelium-derived
(redirected from endothelium-derived constricting factor)

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endothelium-derived
derived from endothelium.

endothelium-derived vasoactive substances
substances produced by or released from endothelial cells which regulate vascular smooth muscle or other regulatory mechanism; include prostacyclin and other prostanoids, angiotensin, and relaxing or constricting factors.
endothelium-derived constricting factor
vasoconstrictive peptides isolated from vascular endothelial cells which are actively vasoconstrictive; endothelin (ET) is the most active of them.
endothelium-derived relaxing factor
several are known; nitrous oxide is one of the chief mediators, probably derived from l-arginine.


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The endothelium-derived constricting factors include a family of three endothelin isoforms (ET-1, ET-2, and ET-3) (55).
 
 
 
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