endothelium-derived

(redirected from endothelium-derived constricting factor)

endothelium-derived

derived from endothelium.

endothelium-derived vasoactive substances
substances produced by or released from endothelial cells which regulate vascular smooth muscle or other regulatory mechanism; include prostacyclin and other prostanoids, angiotensin, and relaxing or constricting factors.
endothelium-derived constricting factor
vasoconstrictive peptides isolated from vascular endothelial cells which are actively vasoconstrictive; endothelin (ET) is the most active of them.
endothelium-derived relaxing factor
several are known; nitrous oxide is one of the chief mediators, probably derived from l-arginine.
References in periodicals archive ?
The endothelium-derived constricting factors include a family of three endothelin isoforms (ET-1, ET-2, and ET-3) (55).
In addition, in the animal model of CB, the observed vasoconstriction could be explained also by a predominant action of endothelium-derived constricting factors.
Thus, vasoconstriction of pulmonary vessels associated with CAPs exposures may be the result of an effect at the level of the pulmonary vascular endothelial cells with an abnormal balance between releasing of endothelium-derived constricting factors and endothelium-derived relaxing factors.

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