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endothelium-derived |
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endothelium-derived derived from endothelium. endothelium-derived vasoactive substances substances produced by or released from endothelial cells which regulate vascular smooth muscle or other regulatory mechanism; include prostacyclin and other prostanoids, angiotensin, and relaxing or constricting factors. endothelium-derived constricting factor vasoconstrictive peptides isolated from vascular endothelial cells which are actively vasoconstrictive; endothelin (ET) is the most active of them. endothelium-derived relaxing factor several are known; nitrous oxide is one of the chief mediators, probably derived from l-arginine. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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endothelium-derived relaxing factor; a naturally occurring gas that in the body is a short-lived dilator substance released from vascular endothelial cells in response to the binding of vasodilators; it inhibits muscular contraction and produces relaxation, and is toxic in the central nervous system. In addition, a number of recent studies of pulmonary endothelium-derived mediators responding to ambient particle exposures have been reported (54). This Phase I, natural history study will examine the contribution of changes in total body fat, enhancement in insulin-mediated vasodilatation, and enhancement in endothelium-derived nitric oxide production to the improvements in metabolic insulin action. |
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