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endothelium-derived

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endothelium-derived
derived from endothelium.

endothelium-derived vasoactive substances
substances produced by or released from endothelial cells which regulate vascular smooth muscle or other regulatory mechanism; include prostacyclin and other prostanoids, angiotensin, and relaxing or constricting factors.
endothelium-derived constricting factor
vasoconstrictive peptides isolated from vascular endothelial cells which are actively vasoconstrictive; endothelin (ET) is the most active of them.
endothelium-derived relaxing factor
several are known; nitrous oxide is one of the chief mediators, probably derived from l-arginine.


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In 1978, he accidentally discovered an element in endothelial cells that relaxes blood vessels, describing it as endothelium-derived relaxing factor, or EDRF.
The vascular endothelium acts as a "plasma-tissue barrier" and has a crucial role in controlling vascular function, with the balance between endothelium-derived vasodilators and vasoconstrictors determining vascular tone and the patholophysiologic consequences (Hurrairah & Ferro, 2004).
NO is known as the endothelium-derived relaxing factor, or EDRF, and a liable free radical with a half-life of about three to five seconds.
 
 
 
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