endothelium-derived

endothelium-derived

derived from endothelium.

endothelium-derived vasoactive substances
substances produced by or released from endothelial cells which regulate vascular smooth muscle or other regulatory mechanism; include prostacyclin and other prostanoids, angiotensin, and relaxing or constricting factors.
endothelium-derived constricting factor
vasoconstrictive peptides isolated from vascular endothelial cells which are actively vasoconstrictive; endothelin (ET) is the most active of them.
endothelium-derived relaxing factor
several are known; nitrous oxide is one of the chief mediators, probably derived from l-arginine.
References in periodicals archive ?
Exercise and endothelial function: role of endothelium-derived nitric oxide and oxidative stress in healthy subjects and hypertensive patients.
ECs play a central role in the regulation of vasomotor tone primarily by the production of Ca 2+-dependent vasodilator signals such as NO, prostaglandins, and endothelium-derived hyperpolarization (EDH).
However, the experiments performed to elucidate whether the endothelium-derived hyperpolarizing factor EDHF could play a role in the vasorelaxant effect to clobenzorex, as previously reported for acetyl-choline (32,33), are discussed below.
We also aimed at investigating whether endothelium-derived NO and antioxidative stress were involved in such effects.
NO, a kind of endogenous endothelium-derived relaxing factor has been found having a vital role in the pathological and physiological process of many diseases.
The healthy endothelium, particularly endothelium-derived nitric oxide, not only modulates the tone of underlying vascular smooth muscle but also inhibits several proatherogenic processes.
In severe cases, topical nitrate preparations have been used to mimic the vasodilatory and protective activity of endothelium-derived nitric oxide.
To investigate the mechanisms involved in CGA-induced relaxation, the contribution of nitric oxide synthase (NOS), cyclooxy-genase (COX) and the endothelium-derived hyperpolarizing factor (EDHF) was assessed in endothelium-intact aortic rings preincubated with the NOS inhibitor, N[omega]-nitro-L-arginine methyl ester (L-NAME, [10.
Vascular dysfunction is characterised by a reduced bioavailability of the endothelium-derived molecule, nitric oxide (NO).
2]S and NO act as endothelial derived hyperpolarizing factors or endothelium-derived relaxing factors [4].
Causes of endothelial dysfunction in nitrate tolerant arteries are well studied, but little is known about mechanisms that underlie the responses to endothelium-derived mediators in nitrate tolerant blood vessels.

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