endothelium-derived

endothelium-derived

derived from endothelium.

endothelium-derived vasoactive substances
substances produced by or released from endothelial cells which regulate vascular smooth muscle or other regulatory mechanism; include prostacyclin and other prostanoids, angiotensin, and relaxing or constricting factors.
endothelium-derived constricting factor
vasoconstrictive peptides isolated from vascular endothelial cells which are actively vasoconstrictive; endothelin (ET) is the most active of them.
endothelium-derived relaxing factor
several are known; nitrous oxide is one of the chief mediators, probably derived from l-arginine.
References in periodicals archive ?
To evaluate the participation of endothelium-derived products in the relaxant effect of EEF, experiments were carried out in the presence of L-NAME (100[mu]M), indomethacin (10[mu]M) or superoxide dismutase (SOD, 300 U/ml), added to the bath 20min prior to the addition of phenylephrine.
The substance responsible for the acetylcholine-stimulated relaxation was initially called endothelium-derived relaxant factor, and subsequently found to include nitric oxide (3,4).
These results suggest that the aqueous extract of MOO vasodilates via nitric oxide pathway with the possible involvement of prostacycline and endothelium-derived hyperpolarizing factor (EDHF) pathways as well.
channel inhibitor, TEA, were used in this study to test the hypothesis that the effect of aqueous hop extract on vasodilation changes was mediated by endothelium-derived hyperpolarizing factor (EDHF).
Together, these findings led us to conclude that HSE induces an endothelium-dependent vasodilation in rat mesenteric artery, by a mechanism dependent on NO, on the activation of potassium channels and endothelium-derived hyperpolarizing factor release.
Sex-specific acute effect of estrogen on endothelium-derived contracting factor in the renal artery of hypertensive Dahl rats.
3A), suggesting that the contractile-effect induced by 7-epiclusianone was dependent on the production of endothelium-derived contractile factors, and that this effect was masked by the production of NO.
It is well-established that NO is a major endothelium-derived relaxing factor, both in vivo and in vitro (Moncada et al.
It is well-established that the release of endothelium-derived relaxing factors (EDRFs) from endothelial cells leads to relaxation of vascular smooth muscle cells and plays a critical role in the maintenance of vascular tone (Moncada and Higgs, 1993).
Tesfariam B, Brown ML, Deykin D, Cohen RA (1990) Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta.
Causes of endothelial dysfunction in nitrate tolerant arteries are well studied, but little is known about mechanisms that underlie the responses to endothelium-derived mediators in nitrate tolerant blood vessels.
2] is another important endothelium-derived relaxing factor so the effect of SC on [PGI.

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