A-receptor which has a high affinity for endothelins
1 and 2, especially for the endothelin
have a half-life on the order of minutes due to rapid clearance from the bloodstream through binding to G-protein-coupled endothelin
B (ETB) receptors in caveolae on the surface of lung capillary endothelial cells (Yamaguchi et al.
The vasoconstrictor endothelin
-1 (ET-1) , a 21-amino acid peptide, is the most abundant member of the family of endothelins
including ET-1, ET-2, and ET-3.
Substantial evidence has been derived from in vitro and animal testing, and, clinical studies suggesting that endothelins
play a pivotal role in distinct cardiovascular diseases.
A decrease in double product was observed in those patients who underwent RPSTs at pre-EECP exercise levels and may be related to the increases in nitric oxide and decrease in endothelins
previously reported by our group.
Various vasoconstrictor mechanisms have been demonstrated, including the release of endothelins
(Bouthillier et al.
The role of endothelins
and their receptors in heart failure.
The family of potent vasoactive and mitogenic peptides, the endothelins
(ETs)  includes at least three isoforms, termed endothelin
-1, -2, and -3 (ET1, ET2, and ET3) and has been thought to play a role in a variety of cardiovascular, renal, and other disorders (1, 2).
The three pre-propeptides undergo a first cleavage into three different big endothelin
(big ET) molecules, followed by a second cleavage (by endothelin
-converting enzyme; ECE) , which yields the three endothelins
ET-1, ET-2, and ET-3 plus their COOH-terminus fragments.
The purpose of this study was to characterize the role of endogenous ET-1 in the vascular system of poultry by investigating the effect of endothelin
A receptor ([ET.
(ET) (1) is a 21-amino acid peptide that has been found to be a potent vasoconstrictor in various vascular beds (1, 2).
(ET) is an endothelial-derived peptide that exerts potent vasoconstrictive activity in vivo and in vitro.