endothelins


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endothelins

A range of peptide substances, containing 21 amino acids, and believed to the most powerful known constrictors of arteries. Very tiny amounts will raise the blood pressure. One of them, ENDOTHELIN-1, derived from the ENDOTHELIUM of blood vessels, also causes constriction of BRONCHI, inhibits the release of RENIN from the kidneys and increases the strength of the heart beat. Endothelins are formed continuously in the larger arteries. Increased output can be caused by oxidized low-density lipoproteins. Endothelin receptors are ubiquitous
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A-receptor which has a high affinity for endothelins 1 and 2, especially for the endothelin 1.
Mature endothelins have a half-life on the order of minutes due to rapid clearance from the bloodstream through binding to G-protein-coupled endothelin B (ETB) receptors in caveolae on the surface of lung capillary endothelial cells (Yamaguchi et al.
The vasoconstrictor endothelin-1 (ET-1) [1], a 21-amino acid peptide, is the most abundant member of the family of endothelins including ET-1, ET-2, and ET-3.
Substantial evidence has been derived from in vitro and animal testing, and, clinical studies suggesting that endothelins play a pivotal role in distinct cardiovascular diseases.
A decrease in double product was observed in those patients who underwent RPSTs at pre-EECP exercise levels and may be related to the increases in nitric oxide and decrease in endothelins previously reported by our group.
Various vasoconstrictor mechanisms have been demonstrated, including the release of endothelins (Bouthillier et al.
The family of potent vasoactive and mitogenic peptides, the endothelins (ETs) [4] includes at least three isoforms, termed endothelin-1, -2, and -3 (ET1, ET2, and ET3) and has been thought to play a role in a variety of cardiovascular, renal, and other disorders (1, 2).
The three pre-propeptides undergo a first cleavage into three different big endothelin (big ET) molecules, followed by a second cleavage (by endothelin-converting enzyme; ECE) [3], which yields the three endothelins ET-1, ET-2, and ET-3 plus their COOH-terminus fragments.
The purpose of this study was to characterize the role of endogenous ET-1 in the vascular system of poultry by investigating the effect of endothelin A receptor ([ET.
Endothelin (ET) (1) is a 21-amino acid peptide that has been found to be a potent vasoconstrictor in various vascular beds (1, 2).
Endothelin (ET) is an endothelial-derived peptide that exerts potent vasoconstrictive activity in vivo and in vitro.