EDN1

(redirected from endothelin 1)

EDN1

A gene on chromosome 6p24.1 that encodes endothelin 1, a potent vasoconstrictor of the endothelin family, which is produced by vascular endothelial cells.
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Conversion of big endothelin 1 to 21-residue endothelin 1 is essential for expression of full vasoconstrictor activity: structure-activity relationships of big endothelin 1.
Plasma endothelin 1,2 levels in mild and severe hypertension.
There is considerable preclinical data suggesting that, compared to either agent alone, simultaneously blocking the actions of both angiotensin II and endothelin 1 may provide significantly improved treatment options for several cardiovascular diseases.
A-receptor which has a high affinity for endothelins 1 and 2, especially for the endothelin 1.
PS433540, the first and only DARA compound in development, selectively blocks the action of two potent vasoconstrictor and mitogenic agents, angiotensin II (AII) and endothelin 1 (ET1), at the AII receptor sub-type 1 and the ET receptor sub-type A, respectively.

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