EDN1

(redirected from endothelin 1)

EDN1

A gene on chromosome 6p24.1 that encodes endothelin 1, a potent vasoconstrictor of the endothelin family, which is produced by vascular endothelial cells.
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Design and synthesis of a specific endothelin 1 antagonist: effects on pulmonary vasoconstriction.
A-receptor which has a high affinity for endothelins 1 and 2, especially for the endothelin 1.
Phosphoramidon inhibits the intracellular conversion of big endothelin 1 to endothelin 1 in cultured endothelial cells.
Conversion of big endothelin 1 to 21-residue endothelin 1 is essential for expression of full vasoconstrictor activity: structure-activity relationships of big endothelin 1.
The compound possesses two clinically validated mechanisms of action that selectively block two potent vasoconstrictor and mitogenic agents, angiotensin II and endothelin 1, at their respective receptors.

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