endothelial dysfunction


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endothelial dysfunction

Failure of the lining of blood vessels and body cavities to carry out normally any of their complex functions including the production of NITRIC OXIDE and ENDOTHELIN-1. Endothelial dysfunction reduces flow-dependent widening of arteries (vasodilatation).
References in periodicals archive ?
An underappreciated factor in the development of cardiovascular disease is endothelial dysfunction.
Nearly 70 million Americans suffer from hypertension, which can be stimulated by endothelial dysfunction -- a condition in which the inner lining of blood vessels does not function normally.
In the first of two related studies, an earlier age of onset for vasomotor symptoms (VMS) was linked with increased endothelial dysfunction as measured by brachial artery ultrasound.
Activation of the endothelium results in the expression and exposure of myriad procoagulant and platelet aggregating factors, adhesion molecules, selectins, integrins, and therefore promotion and propagation of endothelial dysfunction (VEd).
Haiyan Tong, MD, PhD, a research biologist with the United States Environmental Protection Agency, said exposure to airborne particulate matter can lead to endothelial dysfunction, a condition in which the endothelium (inner lining) of blood vessels does not function normally, which is a risk factor for clinical cardiovascular events and progression of atherosclerosis.
Studies have shown that endothelial dysfunction precedes and thought to play a major role in the development of atherosclerosis.
Published in Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy; a new report compared the effects of an aqueous extract of Phyllanthus emblica (Emblica officinalis, amla) versus those of the prescription drug atorvastatin and placebo on endothelial dysfunction and biomarkers of oxidative stress in patients with type II diabetes.
Diminished production or availability of NO and/or imbalance in the relative contribution of endothelium-derived relaxing and contracting factors have been described in endothelial dysfunction (6).
They controlled for demographic characteristics, lifestyle habits, measures of sleep quality and biomarkers of inflammation and endothelial dysfunction.
2) Atherosclerosis begins in young people, and arterial stiffness and endothelial dysfunction are early markers of atherosclerosis.
Vascular dysfunction caused by endothelial dysfunction is an early abnormality in the MetS that may contribute to premature atherosclerosis (2).

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