Another endogenous inhibitor of angiogenesis, endostatin
is generated by MMP3, MMP7, MMP9, MMP13, and MMP20 cleavage of collagen type XVIII [118, 119].
Kolata reported on the findings of Judah Folkman, of Boston Children's Hospital, whose 30 years of work led to the discovery of angiostatin and endostatin
Short-term induction of thrombocytopenia delays periodontal healing in rats with periodontal disease: Participation of endostatin
and vascular endothelial growth factor.
Therapeutic efficacy of endostatin
exhibits a biphasic dose-response curve.
is a potent angiogenesis inhibitor both in vitro and in vivo and has ability to bind [Zn.
That is a crucial step toward the first human trials of endostatin
because it confirms that the compound can be made in sufficient quantities and with characteristics suitable for use in humans.
The study was carried out to determine the senstivity and specificity of oc-fetoprotein (AFP) and Desy-carboxyprothrombine (DCP) as a diagnostic marker for hepacellullar carcinoma (hcc) and to study the angiogenic and antiangiogenic factors like vascular endothlial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin and endostatin
in patients with hcc.
The article concerned two new agents, endostatin
and angiostatin, developed by Harvard Professor judah Folkman, MD.
Some inhibitors are platelet and plasma-derived such as angiostatin, endostatin
, and platelet factor-4 (Daly et al.
Reality testing in cancer treatment: the phase I trial of endostatin
The research, published in the European Respiratory Journal, revealed that talc stimulates healthy cells to produce endostatin
, a hormone considered a magic bullet for treating metastatic lung cancer.
TA Read, DR sorensen, et al, Local endostatin
treatment of gliomas administered by microencapsulated producers cells, Nat Biotechnol, 19, 29-34 (2001).