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An endogenously produced antiangiogenic protein, a proteolytic fragment of collagen XVIII, that inhibits endothelial cell proliferation, angiogenesis and tumor growth, and stimulates endothelial apoptotic cell death. The proapoptoic activity appears to be mediated through tyrosine kinase signaling and a reduction of the antiapoptoic proteins Bcl-2 and Bcl-XL.
[endo- + G. statos, stalled, arrested, + -in]
A potent, naturally occurring antiangiogenic protein that inhibits the formation of the blood vessels that feed tumors. It is under investigation as a potential cancer therapy.
A protein fragment of collagen that contributes to the regulation of blood vessel growth. It is being investigated for its potential to shrink malignant tumors by decreasing their blood supply.