endostatin


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endostatin

(en'dō-stat-in),
An endogenously produced antiangiogenic protein, a proteolytic fragment of collagen XVIII, that inhibits endothelial cell proliferation, angiogenesis and tumor growth, and stimulates endothelial apoptotic cell death. The proapoptoic activity appears to be mediated through tyrosine kinase signaling and a reduction of the antiapoptoic proteins Bcl-2 and Bcl-XL.
[endo- + G. statos, stalled, arrested, + -in]

endostatin

(ĕn′dō-stăt′n)
n.
A potent, naturally occurring antiangiogenic protein that inhibits the formation of the blood vessels that feed tumors. It is under investigation as a potential cancer therapy.

endostatin

(ĕn″dŏ-stăt′ĭn)
A protein fragment of collagen that contributes to the regulation of blood vessel growth. It is being investigated for its potential to shrink malignant tumors by decreasing their blood supply.

endostatin

A substance that interferes with the development of the lining of blood vessels (endothelium). Since cancers require blood vessels to grow and tumour endothelium divides up to 50 times faster than normal endothelium, this substance offers promise as an anticancer drug. Trials in mice have been remarkably promising and human trials are under way. See also ANGIOSTATIN.
References in periodicals archive ?
Serum VEGF, bFGF, angiogenin and endostatin levels were estimated in 60 HCC patients with mean age 57.
Angiostatin and endostatin have not lived up to expectations.
Less than one day after treatment with talc, patients began producing 10-fold higher levels of endostatin, a hormone released by healthy lung cells.
In an interesting study, Zhao, et al, evaluated S-VEGF (by ELISA) and endostatin levels (by competitive enzyme immunoassay) in 59 breast-cancer patients before surgery and three weeks following surgery.
Under the terms of the agreement, Oxford BioMedica receives exclusive worldwide rights to use EntreMed's endostatin and angiostatin genes in the development of locally delivered gene therapy for ophthalmologic applications.
The assay is equally useful for testing inhibitory factors, such as endostatin or TNP 470, and motility-enhancing factors, such as fibroblast growth factor-2 (FGF-2) or vascular endothelial growth factor (VEGF), and because of its ease, permits utilization of several different endothelial and nonendothelial cell types to control for specificity of the observed response.
Anderson Cancer Center labeled the experimental drug endostatin with a radioactive tag.
The pilot clinical studies implied that endostatin and angiostatin may work too slowly to be clinically useful, said Dr.
Last year, encouraging results were reported after the first human trial of the cancer drug endostatin, developed in Folkman's lab.
Much to Folkman's dismay, endostatin was touted in the New York Times as a potential cancer cure, creating immense pressure to speed up the research.
He extracted enough of the proteins from mouse urine to make two drugs that he calls angiostatin and endostatin.