endostatin


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endostatin

(en'dō-stat-in),
An endogenously produced antiangiogenic protein, a proteolytic fragment of collagen XVIII, that inhibits endothelial cell proliferation, angiogenesis and tumor growth, and stimulates endothelial apoptotic cell death. The proapoptoic activity appears to be mediated through tyrosine kinase signaling and a reduction of the antiapoptoic proteins Bcl-2 and Bcl-XL.
[endo- + G. statos, stalled, arrested, + -in]

endostatin

(ĕn′dō-stăt′n)
n.
A potent, naturally occurring antiangiogenic protein that inhibits the formation of the blood vessels that feed tumors. It is under investigation as a potential cancer therapy.

endostatin

(ĕn″dŏ-stăt′ĭn)
A protein fragment of collagen that contributes to the regulation of blood vessel growth. It is being investigated for its potential to shrink malignant tumors by decreasing their blood supply.

endostatin

A substance that interferes with the development of the lining of blood vessels (endothelium). Since cancers require blood vessels to grow and tumour endothelium divides up to 50 times faster than normal endothelium, this substance offers promise as an anticancer drug. Trials in mice have been remarkably promising and human trials are under way. See also ANGIOSTATIN.
References in periodicals archive ?
Another endogenous inhibitor of angiogenesis, endostatin is generated by MMP3, MMP7, MMP9, MMP13, and MMP20 cleavage of collagen type XVIII [118, 119].
Kolata reported on the findings of Judah Folkman, of Boston Children's Hospital, whose 30 years of work led to the discovery of angiostatin and endostatin.
Short-term induction of thrombocytopenia delays periodontal healing in rats with periodontal disease: Participation of endostatin and vascular endothelial growth factor.
Endostatin is a potent angiogenesis inhibitor both in vitro and in vivo and has ability to bind [Zn.
That is a crucial step toward the first human trials of endostatin because it confirms that the compound can be made in sufficient quantities and with characteristics suitable for use in humans.
The study was carried out to determine the senstivity and specificity of oc-fetoprotein (AFP) and Desy-carboxyprothrombine (DCP) as a diagnostic marker for hepacellullar carcinoma (hcc) and to study the angiogenic and antiangiogenic factors like vascular endothlial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin and endostatin in patients with hcc.
The article concerned two new agents, endostatin and angiostatin, developed by Harvard Professor judah Folkman, MD.
Some inhibitors are platelet and plasma-derived such as angiostatin, endostatin, and platelet factor-4 (Daly et al.
The research, published in the European Respiratory Journal, revealed that talc stimulates healthy cells to produce endostatin, a hormone considered a magic bullet for treating metastatic lung cancer.
TA Read, DR sorensen, et al, Local endostatin treatment of gliomas administered by microencapsulated producers cells, Nat Biotechnol, 19, 29-34 (2001).