endopeptidase


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Related to endopeptidase: neutral endopeptidase

endopeptidase

 [en″do-pep´tĭ-dās]
any peptidase that catalyzes the cleavage of internal bonds in a polypeptide or protein. Inhibition of the action of endopeptidases (proteases) in viruses causes formation of noninfectious particles; certain antiviral drugs work in this way (see protease inhibitors). Called also protease and proteinase.

en·do·pep·ti·dase

(en'dō-pep'ti-dās),
An enzyme that catalyzes the hydrolysis of a peptide chain at points well within the chain, not near either terminus; for example, pepsin, trypsin. Compare: exopeptidase.
Synonym(s): proteinase

endopeptidase

/en·do·pep·ti·dase/ (-pep´tĭ-dās) protease; any peptidase that catalyzes the cleavage of internal bonds in a polypeptide or protein.

endopeptidase

(ĕn′dō-pĕp′tĭ-dās′, -dāz′)
n.
Any of a large group of enzymes that catalyze the hydrolysis of peptide bonds in the interior of a polypeptide chain or protein molecule.

endopeptidase

[en′dōpep′ti·dās]
Etymology: Gk, endon, within + Gk, peptein, to digest + ase, enzyme suffix
any peptidase that catalyzes the cleavage of internal peptide bonds in a polypeptide or protein. Endopeptidases are divided into subclasses on the basis of catalytic mechanism and comprise the serine endopeptidases, cysteine endopeptidases, aspartic endopeptidases, metalloendopeptidases, and other endopeptidases.

en·do·pep·ti·dase

(en'dō-pep'ti-dās)
An enzyme catalyzing the hydrolysis of a peptide chain at points well within the chain, not near termini (e.g., pepsin, trypsin).
Compare: exopeptidase

endopeptidase

or

proteinase

a type of PROTEASE (protein-splitting enzyme) that hydrolyses peptide bonds between particular amino acids located inside the chain, but not at the ends. There are three major endopeptidases in the mammalian gut: PEPSIN (stomach); TRYPSIN and CHYMOTRYPSIN (pancreas). Such enzymes are responsible for the first stage of protein digestion; other proteases called EXOPEPTIDASES complete the digestion of protein in the ILEUM.

endopeptidase

a peptidase capable of acting on any peptide linkage in a peptide chain.
References in periodicals archive ?
This press release contains "forward-looking statements," including, but not limited to, the statements by Dr Melanie Lee and other statements regarding clinical development, marketing and sales of Allergan's Re-Targeted Endopeptidase Drug candidate AGN-214868.
Based on the substrate information, several small peptides have been developed as competitive inhibitors for the BoNT endopeptidase activity.
For the Endopep-MS method, BoNT serotypes A, B, E, and F endopeptidase activities were determined in 20-[micro]L volumes of buffer containing 0.
Components of biologic variation in prolyl endopeptidase and dipeptidyl-peptidase IV activity in plasma of healthy subjects.
4), an endopeptidase that hydrolyzes only Lys and Arg bonds (Taghizadeh et al.
Atrial natriuretic peptides cleaved by endopeptidase are inactive in conscious spontaneously hypertensive rats.
This enzyme is an exopeptidase with endopeptidase and glutaminase side activities.
PhytoMemory inhibited prolyl endopeptidase (PEP), which has been previously characterized as a promising therapeutic target for supporting learning, memory, and mood.
Pipeline candidates fall under major therapeutic classes such as endotheline receptor antagonist, vasopeptidase inhibitor, vaccine, glycogen synthase kinase 3 beta (GSK3B) inhibitor (monoclonal antibody), peroxisome proliferator activator receptor (PPAR) agonist, chaperone activator, aldosterone synthase inhibitor, sodium dependent glucose cotransporter 2 inhibitor, natriuretic peptide receptor agonist, opioid-1 (ORL1) agonist, nuclear endopeptidase inhibitor, ouabain antagonist, MAS G protein-coupled receptor (GPCR) agonists and RAAS inhibitors
Induction of neutral endopeptidase and angiotensin-converting enzyme activity of SK-N-SH cells in vitro by quercetin and resveratrol.
Neutral endopeptidase (NEP) inhibitors also are being given a second look, this time in combination with ARBs.
III] peroxisomal membrane Protease, serine, PRSS11 Serine-type 11 (IGF binding) endopeptidase activity, regulation of cell cycle [DMA.