endopeptidase


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Related to endopeptidase: neutral endopeptidase

endopeptidase

 [en″do-pep´tĭ-dās]
any peptidase that catalyzes the cleavage of internal bonds in a polypeptide or protein. Inhibition of the action of endopeptidases (proteases) in viruses causes formation of noninfectious particles; certain antiviral drugs work in this way (see protease inhibitors). Called also protease and proteinase.

en·do·pep·ti·dase

(en'dō-pep'ti-dās),
An enzyme that catalyzes the hydrolysis of a peptide chain at points well within the chain, not near either terminus; for example, pepsin, trypsin. Compare: exopeptidase.
Synonym(s): proteinase

endopeptidase

/en·do·pep·ti·dase/ (-pep´tĭ-dās) protease; any peptidase that catalyzes the cleavage of internal bonds in a polypeptide or protein.

endopeptidase

(ĕn′dō-pĕp′tĭ-dās′, -dāz′)
n.
Any of a large group of enzymes that catalyze the hydrolysis of peptide bonds in the interior of a polypeptide chain or protein molecule.

endopeptidase

[en′dōpep′ti·dās]
Etymology: Gk, endon, within + Gk, peptein, to digest + ase, enzyme suffix
any peptidase that catalyzes the cleavage of internal peptide bonds in a polypeptide or protein. Endopeptidases are divided into subclasses on the basis of catalytic mechanism and comprise the serine endopeptidases, cysteine endopeptidases, aspartic endopeptidases, metalloendopeptidases, and other endopeptidases.

en·do·pep·ti·dase

(en'dō-pep'ti-dās)
An enzyme catalyzing the hydrolysis of a peptide chain at points well within the chain, not near termini (e.g., pepsin, trypsin).
Compare: exopeptidase

endopeptidase

or

proteinase

a type of PROTEASE (protein-splitting enzyme) that hydrolyses peptide bonds between particular amino acids located inside the chain, but not at the ends. There are three major endopeptidases in the mammalian gut: PEPSIN (stomach); TRYPSIN and CHYMOTRYPSIN (pancreas). Such enzymes are responsible for the first stage of protein digestion; other proteases called EXOPEPTIDASES complete the digestion of protein in the ILEUM.

endopeptidase

a peptidase capable of acting on any peptide linkage in a peptide chain.
References in periodicals archive ?
Comparison of the hydrolysis of the three types of natriuretic peptides by human kidney neutral endopeptidase 24.
The report reviews Neprilysin (Neutral Endopeptidase 24.
The next task was to identify the major responsible A[beta]-degrading peptidase among members of the neutral endopeptidase family.
These agents inhibit angiotensin-converting enzyme as well as neutral endopeptidase, an enzyme that helps rid the body of excess salt and water and would lower the blood pressure, she said.
Exopeptidases have also been shown to play an important role in petal senescence and the levels of exopeptidase and endopeptidase activities have been found to be developmentally regulated (Mahagamasekera & David, 2001).
Induction of neutral endopeptidase and angiotensin-converting enzyme activity of SK-N-SH cells in vitro by quercetin and resveratrol.
dependent neutral endopeptidase family that degrades ECM components and plays an essential role in SMC proliferation and migration (5, 6).
Other ways for a rise of tachykinins in these patients include the reduced effect of neutral endopeptidase, an enzyme that is important in degrading and inactivating tachykinins.
11,12) Expression of the glycoprotein endopeptidase CD10 is rare in IPMN and common in MCN (9); here, this marker was diffusely positive in an apical, membranous pattern.
in the nerve cells, has been utilized in a novel 'second generation' ELISA, the endopeptidase assay (117).
In vivo effects of lambda-cyhalothrin on proteases of various body compartments showed that almost all proteases in the gut, except cathepsin B, showed considerably elevated levels ranging from 19% in the case of proline endopeptidase and 429% in the case of DAP I.