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endonuclease |
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endonuclease /en·do·nu·cle·ase/ (-noo´kle-ās) any nuclease specifically catalyzing the hydrolysis of interior bonds of ribonucleotide or deoxyribonucleotide chains. restriction endonuclease an endonuclease that hydrolyzes DNA, cleaving it at an individual site of a specific base pattern.
endonuclease, an enzyme that cleaves or hydrolyzes phosphodiester bonds within a polynucleotide chain. Compare exonuclease. endonuclease (en´dōnoo´klēās´), n an enzyme (nuclease) that cleaves polynucleotides at interior bonds, producing polynucleotide or oligonucleotide fragments. endonuclease a nuclease that cleaves internal bonds of polynucleotides. restriction endonuclease How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Although the intrinsic pathway involves early activation of caspase-9, and the extrinsic pathway is mediated through caspase-8, both lead to activation of the "executioner" caspase-3 and a variety of proteases and endonucleases. Increased expression of apurinic and apyrimidinic (AP) endonuclease (~ 5-fold) indicates possible activation of DNA repair processes (He et al. These include restriction endonucleases for cleaving DNA and ligases for joining the fragments, recombinases that can execute a large variety of DNA cleavage and joining reactions. |
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