endometrial hyperplasia


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endometrial hyperplasia

increase in the number of endometrial glands, usually secondary to hyperestrinism; classified as simple hyperplasia, complex hyperplasia, or complex hyperplasia with atypia; the latter may progress to adenocarcinoma.

endometrial hyperplasia

an abnormal condition characterized by overgrowth of the endometrium resulting from sustained stimulation by estrogen (of endogenous or exogenous origin) that is not opposed by progesterone. Estrogen acts as a growth hormone for the endometrium. Through a complex intercellular mechanism, endometrial cells bind estrogen preferentially and undergo changes characteristic of the proliferative phase of the menstrual cycle. If estrogen stimulation continues for 3 to 6 months without periodic cessation or counteractive progesterone stimulation, as occurs in anovulatory or perimenopausal women and in those receiving replacement estrogen without added progestogen, the endometrium becomes abnormally thickened and glandularized. Unremitting estrogen stimulation eventually causes cystic or adenomatous endometrial hyperplasia. The latter is a premalignant lesion that undergoes malignant degeneration in approximately 25% of cases. The causative relationship between estrogen and endometrial hyperplasia is well established; there is some indication but no proof that estrogen also provokes the change from hyperplasia to neoplasia and malignancy. Endometrial hyperplasia often results in abnormal uterine bleeding. Such bleeding, particularly in older women, constitutes an indication for biopsy or curettage of the endometrium to establish histopathological diagnosis and to rule out malignancy. A functioning estrogen-secreting tumor is suspected if the woman is not taking estrogen medication. Progestogen therapy is effective in reversing the abnormal histopathological changes of endometrial hyperplasia. If hyperplasia is adenomatous, hysterectomy is commonly performed.

endometrial hyperplasia

Adenomatous hyperplasia of endometrium Gynecology A premalignant endometrial lesion of older ♀
Endometrial hyperplasia
Hyperplasia without atypia Glands are crowded w/o cytologic atypia; these have a < 2% progress to carcinoma
Simple hyperplasia Glands are not back-to-back
Complex hyperplasia Glands are back-to-back
Hyperplasia with atypia Glands are crowded with cytologic atypia; ± 23% progress to carcinoma

en·do·me·tri·al hy·per·pla·si·a

(en'dō-mē'trē-ăl hī'pĕr-plā'zē-ă)
Increase in the number of endometrial glands, usually secondary to hyperestrinism; classified as simple hyperplasia, complex hyperplasia, or complex hyperplasia with atypia; the latter may progress to adenocarcinoma.
References in periodicals archive ?
This common gynecological procedure helps in the diagnosis of conditions such as abnormal menstrual bleeding, pelvic tenderness, endometrial hyperplasia, and uterine cancer.
As a consequence of the obesity epidemic, younger women are being diagnosed with endometrial hyperplasia and cancer.
Then again, Gloria might have endometrial hyperplasia, a condition where the lining of the uterus becomes thick and bleeding may occur.
They maybe preceded by hyperplasia, atypical hyperplasia, and endometrial intraepithelial neoplasia, which is a premalignant outgrowth from benign endometrial hyperplasia [reviewed in (24)].
The aim of this study was to determine if long-term isoflavone soy protein (ISP) in supplement form could affect endometrial thickness, endometrial hyperplasia, and endometrial cancer in postmenopausal women.
Incorporating color histopathology sections throughout, she covers interpreting results and communication between the pathologist and clinician, the normal endometrial cycle, pregnancy-related findings in normal and abnormal pregnancies, organic lesions, hormonally-related abnormal uterine bleeding, endometrial hyperplasia and preinvasive disease, malignancies, diagnostic pitfalls, and molecular aspects.
These problems include uterine fibroids (benign tumors), endometriosis and endometrial hyperplasia, an abnormal thickening of the lining of the uterus that can lead to uterine cancer.
It should be kept in mind that Tamoxifen intake may induce endometrial hyperplasia, polyps, and carcinomas.
While this is effective in reducing osteoclast activity and development of osteoporosis, it can lead to endometrial hyperplasia and subsequent adenocarcinoma.
A subsequent hysterectomy was diagnosed with focally complex, endometrial hyperplasia with mild cytologic atypia.
Histopathological examination of the polyps in this group revealed only 1 case of endometrial hyperplasia (3.
Preterm labour, male and female factors underlying recurrent pregnancy losses, endometrial hyperplasia, cancers of endometrium, ovary, cervix and prostate cancers, adult onset of fetal diseases, genital tuberculosis and congenital abnormalities of male reproductive tract are the areas which need attention.