endometrial biopsy

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Related to endometrial biopsy: Endometrial ablation, Endometrial hyperplasia

Endometrial Biopsy



Endometrial biopsy is a procedure in which a sample of the endometrium (tissue lining the inside of the uterus) is removed for microscopic examination.


The test is most often performed to find out the cause of abnormal uterine bleeding. Abnormal bleeding includes bleeding between menstrual periods, excessive bleeding during a menstrual period, or bleeding after menopause. Since abnormal uterine bleeding can indicate cancer, an endometrial biopsy is done to rule out endometrial cancer or hyperplasia (a potentially precancerous condition).
Endometrial biopsies are also done as a screening test for endometrial cancer in postmenopausal women on hormone replacement therapy. Hormone replacement therapy usually requires a woman to take estrogen and progesterone. An endometrial biopsy is particularly useful in cases where postmenopausal women take estrogen, but cannot take progesterone. Estrogen in the system without the balancing effect of progesterone has been linked to an increased risk of endometrial cancer.
An endometrial biopsy can also be used as part of an infertility exam to rule out problems with the development of the endometrium. This condition is called luteal phase defect and can cause the endometrium to not support a pregnancy. An endometrial biopsy can also be used to evaluate the problem of repeated early miscarriages.


If the endometrial biopsy is being done to investigate why a woman is unable to get pregnant, the test must be performed at a specific time during the menstrual cycle. Since the test evaluates whether the endometrium is developed adequately to support implantation and growth of a fertilized egg, it is critical to perform the test approximately three days before the expected menstrual period.


The test is performed by a doctor who specializes in women's reproductive health (an obstetrician/gynecologist). The test is performed either in the doctor's office or in a local hospital. The patient may be asked to take pain medication (like Motrin or Aleve) an hour or so before the procedure. A local anesthetic may be injected into the cervix in order to decrease pain and discomfort during the procedure.
The woman will be asked to lie on her back with knees apart and feet in stirrups. The doctor will first conduct a thorough exam of the pelvic region, including the vulva (the external genitals), vagina, and uterus. A speculum (an instrument that is used to hold the walls of the vagina open) will be inserted into the vagina. A small, hollow plastic tube is then passed into the uterine cavity. A small piece of the uterine lining is sucked out with a plunger that is attached to the tube. Once the sample is obtained, the instruments are removed. The sample is sent to the laboratory for microscopic examination.
The patient may experience some pain when the cervix is grasped. The patient may also feel some cramping, pressure, and discomfort when the instruments are inserted into the uterus and the tissue sample is collected.


For the small number of endometrial biopsies that are done as part of infertility testing, a pregnancy test is also often performed before the procedure. Since the biopsy is performed late in the menstrual cycle, it is possible that the woman may be pregnant.


The biopsy may cause a small amount of bleeding (spotting). The woman can resume normal activities right away. If cramping becomes severe, heavy bleeding occurs, or the woman develops a high temperature, the doctor should be notified immediately.
If the test is being done to determine the cause of infertility, the onset of the menstrual period following the biopsy should be reported to the doctor. This will allow the doctor to correctly predict if the endometrium has been developing at the expected rate.


The risks of an endometrial biopsy are very small. There is a possibility that prolonged bleeding may occur after the procedure. There is also a slight chance of an infection. Very rarely, there are instances when the uterus is pierced (perforated) or the cervix is torn because of the biopsy.
A catheter is inserted into the uterus to remove uterine cells for further examination.
A catheter is inserted into the uterus to remove uterine cells for further examination.
(Illustration by Argosy Inc.)

Normal results

Most biopsies are done to rule out endometrial cancer or endometrial hyperplasia. A normal result shows no cancerous or precancerous cells. Normal results also show that the uterine lining is changing at the proper rate. If it is, then the results of the biopsy are said to be "in-phase" because the tissue looks appropriate and has developed normally for the late phase of the menstrual cycle.

Abnormal results

If the endometrium is not developing at the appropriate rate, the results are said to be "out-of-phase" or abnormal. The endometrium has not developed appropriately and cannot support a pregnancy. This condition is called luteal phase defect and may need to be treated with progesterone.
Abnormal appearance of the cells forming the uterine tissue could also indicate uterine cancer, or the presence of fibroids or polyps in the uterus.

Key terms

Biopsy — The surgical removal and microscopic examination of living tissue for diagnostic purposes.
Cervix — The opening of the uterus extending into the vagina.
Endometrium — The layer lining the inner cavity of the uterus; this layer changes daily throughout the menstrual cycle.
Uterus — The hollow, muscular female organ that supports the development and nourishment of the unborn baby during pregnancy.



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endometrial biopsy

a microscopic examination of a sample of endometrial tissue to assess corpus luteum function. It is performed in infertile women with regular ovulatory cycles and no identifiable reason for infertility, in women with repeated first trimester abortions, in cases of abnormal vaginal bleeding, and during ovulation induction therapy.

endometrial biopsy

Gynecology The sampling of endometrial tissue to evaluate abnormal menses, heavy menstruation or post-menopausal bleeding, infertility Findings Endometrial CA, hyperplasia, uterine fibroids, endometrial polyps


pertaining to or emanating from the endometrium.

endometrial biopsy
punch biopsy specimens obtained in the mare and cow by passing the instrument through the cervix and controlling the site of the biopsy by a hand in the rectum.
endometrial cups
ulcer-like structures in the endometrium of the pregnant mare. They are produced by the fetus but become detached from it. Their function is to produce equine gonadotropin, formerly PMSG.
endometrial curettage
débridement of the endometrium by metal curette is not practiced in animals but a chemical equivalent, by the infusion of irritant substances, is used instead.
endometrial cyst
in cows and ewes near caruncles; develop during uterine involution due to adhesions from the caruncle; no clinical importance.
cystic endometrial hyperplasia
pathological hyperplasia of endometrium, as distinct from the physiological state, due in most instances to excessive and prolonged estrogenic stimulation; characterized by thickening of the endometrium, development of mucus-filled glands and the accumulation of mucus in the lumen of the uterus. Associated with cystic ovarian disease in cows. In ewes it is usually due to prolonged low level intake of phyto-estrogens, e.g. on subterranean clover pasture. It may be a precursor of or associated with pyometra, especially in the dog where the hormonal cause is progesterone. See also pyometra.
endometrial folds
in the mare these run the length of the uterus as observed by fiberscope.
endometrial glands
provide uterine fluid (histotrophe) on which the developing fetus depends for subsistence during its first few days of existence.
endometrial hyperplasia with pyometra
see cystic endometrial hyperplasia.
endometrial polyp
found in the bitch and may cause prolapse of the affected horn with the polyp visible in the vagina.
endometrial regeneration
postpartum return to normal of the endometrium, e.g. in cows by the sloughing of superficial layers of caruncles.
References in periodicals archive ?
Dijkhuizen et al (20) conducted a metaanalysis by examining 39 studies that included 8000 patients who underwent endometrial biopsy and compared results with those from D&C, hysteroscopy, or hysterectomy.
Endometrial biopsy has long been the gold standard for diagnosis, but it is an uncomfortable procedure for an older patient, especially if cervical stenosis is present.
If a woman with a uterus takes estrogen alone, she should have a yearly endometrial biopsy because of the risk of serious hyperplasias--this is vital for good health.
In addition, patient discomfort was significantly reduced as the need to re-insert the speculum and place in a different catheter for collection of material for the endometrial biopsy was eliminated.
Infertile patients with good response to controlled ovarian hyper-stimulation (COH) but with one or two unsuccessful IVF/ET attempts were treated at least 4 times by endometrial biopsy using a biopsy catheter (pipelle device) during the menstrual cycle, before the next IVF-ET cycle.
Offering a postmenopausal patient a choice between a biopsy and a transvaginal ultrasound is reasonable as long as either procedure is available quickly and the patient understands that she still may need an endometrial biopsy after an ultrasound.
Endometrial biopsy at 6 months showed an inactive endometrium.
For the purposes of the current analysis, "those women with endometritis on the initial biopsy were asked to come back 12 weeks after treatment to undergo a second endometrial biopsy," Dr.
To emphasize practical aspects of endometrial specimen handling and reporting, with selected comments on common diagnostic pitfalls, including (1) the diagnosis of endometrial intraepithelial carcinoma in atrophic endometrial biopsy specimens, (2) evaluation of adequacy of endometrial sampling specimens, (3) problems in diagnosing and measuring the depth of myometrial invasion in endometrial carcinoma, (4) the question of metastasis versus independent primaries in concurrent carcinomas of endometrium and one or both ovaries, (5) the problematic differential diagnoses between type 1 (primarily endometrioid) and type 2 (primarily serous) adenocarcinomas, and (6) atypical hyperplasia and proposed classification systems for its replacement.
A 70-year-old white woman, gravida 2 para 2, was referred to our gynecologic oncology service after her general obstetrician/gynecologist diagnosed adenocarcinoma of the endometrium by endometrial biopsy after postmenopausal bleeding.
NasdaqGM:RPRX) today released the endometrial biopsy findings from its three and six month studies of Proellex[TM] in the treatment of uterine fibroids and endometriosis respectively.
Nasdaq: CBRX) ("Columbia" or "the Company"), a specialty pharmaceutical company focused on the development of pharmaceuticals for women's health, plans to initiate a Phase II clinical trial for COL-1077, a lidocaine bioadhesive 10% gel, in women undergoing transvaginal pipelle-directed endometrial biopsy in the second quarter of 2015.