Another eight rats underwent a similar procedure without implantation of the endoluminal sleeve.
With a view to determining whether the endoluminal sleeve could prevent obesity, the research team implanted the device in rats genetically prone to rapid weight gain but lean since they had been brought up on a low-fat diet.
The coming year should bring new information on the endoluminal sleeve
, known as the EndoBarrier Gastrointestinal Liner, now in late-stage clinical trials.
GI Dynamics, a medical device company pioneering the development of new approaches to treat obesity and type 2 diabetes, announced today a paper appearing in the advance online publication of the journal Obesity, which demonstrates that implantation of an innovative endoluminal sleeve mimics key, beneficial effects of Roux-en-Y gastric bypass (RYGB) surgery, inducing substantial weight loss and improved metabolic function in rats with diet-induced obesity.
Obesity: " An Endoluminal Sleeve Induces Substantial Weight Loss and Normalizes Glucose Homeostasis in Rats with Diet-Induced Obesity," by Aguirre et al.