endoglin


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en·do·glin

(en'dō-glin), [MIM*131195]
A protein on the surface of endothelial cells that binds to transforming growth factor-β.

en·do·glin

(en'dō-glin)
A protein on the surface of endothelial cells that binds to transforming growth factor-β.

endoglin

An antiangiogenic protein. A rise in the circulating level of soluble endoglin heralds the onset of PRE-ECLAMPSIA within two to three months.
References in periodicals archive ?
We are extremely pleased both with the outcome of our collaborative research program with Alere, and their continued interest in pursuing a commercialization strategy for the biomarker Endoglin as an important contributor to a test that can help to identify at risk mothers for Preeclampsia early in their pregnancy, commented Christopher J.
Endoglin, PlGF and sFlt-1 as markers for predicting pre-eclampsia.
Those women had blood concentrations of soluble endoglin that were nearly double those found in women who had uncomplicated pregnancies.
TRC105 is an antibody that inhibits a novel target, endoglin, a key mediator of resistance to VEGF inhibitor treatment in angiogenesis-driven diseases.
We believe that soluble endoglin [a cell surface receptor for the proangiogenic protein transforming growth factor-[beta] and soluble fms-like tyrosine kinase 1 [an antiangiogenic factor that binds placental growth factor and vascular endothelial growth factor] act in concert to produce the maternal syndrome or preeclampsia," he said.
Familial disease are usually due to mutations in the bone morphogenic protein receptor type 2 (BMPR2), activin-like kinase-type 1 (ALK1) and endoglin (ENG).
The primary mouse monoclonal antibody was anti-human endoglin (CD105) (M3527, clone SN6h, Dako) used at a 1: 500 dilution ratio.
TRC105, a novel monoclonal antibody to endoglin (CD105), is being studied in multiple clinical trials in combination with agents that target the VEGF pathway.
Circulatory soluble endoglin and its predictive value for preeclampsia in second-trimester pregnancies with abnormal uterine perfusion.
2 ALK1, endoglin (kalitsal hemorajik telenjiyektazi ile birlikte veya tek basina) 1.
sFlt1 and soluble endoglin as biomarkers of preeclampsia 167
In addition, agglomerative, unbiased 5 Human genes: ENG, endoglin (Osler-Rendu-Weber syndrome 1); ACVRLI, activin A receptor type 11-like 1.