pyrogen

(redirected from endogenous pyrogen (EP))
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pyrogen

 [pi´ro-jen]
an agent that causes fever; called also pyretic and pyrectic. adj., adj pyrogen´ic.
endogenous pyrogen a low-molecular-weight protein that is produced by phagocytic leukocytes in response to stimulation by exogenous pyrogens and released into the circulation; it induces fever by acting on the preoptic area of the hypothalamus to raise the set-point of the hypothalamic thermostat. The pyrogen produced by monocytes and macrophages is not identical to that produced by neutrophils and eosinophils; the mononuclear phagocytes also produce a greater amount of pyrogen for a longer period of time than do the polymorphonuclear cells.
exogenous p's fever-producing agents of external origin, e.g., bacterial endotoxins and other microbial products, antigen-antibody complexes, viruses and synthetic polynucleotides, incompatible blood and blood products, and androgen breakdown products such as etiocholanolone; the action is mediated by endogenous pyrogen.

py·ro·gen

(pī'rō-jen),
A fever-inducing agent; pyrogens are produced by bacteria, molds, viruses, and yeasts.
[pyro- + G. -gen, producing]

pyrogen

/py·ro·gen/ (pi´ro-jen) a fever-producing substance.

pyrogen

(pī′rə-jən)
n.
A substance that produces fever.

pyrogen

[pī′rəjən]
Etymology: Gk, pyr, fire, genein, to produce
any substance or agent that tends to cause a rise in body temperature, such as some bacterial toxins. See also fever. pyrogenic, adj.

pyrogen

 A fever-inducing substance

py·ro·gen

(pī'rō-jen)
A fever-inducing agent; produced by bacteria, molds, viruses, and yeasts; commonly found in distilled water.
[pyro- + G. -gen, producing]

pyrogen

Any substance that causes fever. Endogenous pyrogens are proteins, such as interleukin-1, released by white blood cells in response to bacterial or viral infections. These act on the temperature-regulating centre in the brain, effectively resetting the thermostat at a higher level and causing the muscles to contract repeatedly and rapidly (shivering) so as to raise body temperature.

pyrogen

any substance which alters the body thermostat of HOMOIOTHERMS to a higher setting, giving rise to fever.

Pyrogen

A chemical circulating in the blood that causes a rise in body temperature.
Mentioned in: Fever

py·ro·gen

(pī'rō-jen)
Fever-inducing agent; produced by bacteria, molds, viruses, and yeasts.
[pyro- + G. -gen, producing]

pyrogen

an agent that causes fever.

endogenous pyrogen (EP)
the mediator of fever, produced by polymorphonuclear leukocytes, monocytes and macrophages.
exogenous pyrogen
lipopolysaccharides and other substances produced by pathogenic microorganisms.